Achiam Michael, Holm Jakob, Svendsen Lars Bo
Kirurgisk Gastroenterologisk Klinik, Rigshospitalet, Blegdamsvej 9, 2100 København Ø.
Ugeskr Laeger. 2014 Jan 6;176(2A):V06130409.
Barrett's esophagus (BE) with dysplasia is generally accepted as the precursor to oesophageal cancer. Thus, methods to eradicate BE and dysplasia have been evaluated. Recently, radiofrequency ablation (RFA) has shown promising results with few adverse effects. The studies concerning RFA are, however, small and heterogeneous. Only six studies have included more than 100 patients and only one is a prospective randomized trial. The purpose of this article is to describe the treatment of BE and especially the indications and challenges of RFA, including complications, buried glands and recurrence.
伴有发育异常的巴雷特食管(BE)通常被认为是食管癌的前驱病变。因此,人们对根除BE和发育异常的方法进行了评估。最近,射频消融(RFA)已显示出良好的效果且不良反应较少。然而,有关RFA的研究规模较小且具有异质性。仅有六项研究纳入了超过100例患者,且只有一项是前瞻性随机试验。本文的目的是描述BE的治疗方法,尤其是RFA的适应证和挑战,包括并发症、隐匿性腺管和复发情况。