Angell Vázquez del Mercado M
Pract Odontol. 1989 Dec;10(12):35-7.
The effects of bacterial plaque on the immunologic response are varied and complex, which is astounding considering the nature of the plaque. The large number of gram-positive and gram-negative bacteria and their products like lipopolysaccharides (LPS), lipoteicoic acids (LTA), dextrans and levanes, permit the activation of most immunologic mechanisms. Both the classical and alternate paths in the complement system are activated, as well as lymphocytes, macrophages, and lymphocyne liberation. Polyclonal mitogens evolving to B lymphocytes may perform an important function in lymphocyte stimulation. An immunogenetic control over the functions of T auxiliary cells has been suggested, with at least one antigen from plaque, and related to the HLA-DR. These reactions may be modulated through potentiating and suppressing effects of some plaque components, thus resulting in a chronic localized inflammatory response.
细菌菌斑对免疫反应的影响多样且复杂，考虑到菌斑的性质，这令人惊讶。大量革兰氏阳性菌和革兰氏阴性菌及其产物，如脂多糖（LPS）、脂磷壁酸（LTA）、葡聚糖和果聚糖，可激活大多数免疫机制。补体系统的经典途径和替代途径均被激活，淋巴细胞、巨噬细胞以及淋巴细胞释放也被激活。作用于B淋巴细胞的多克隆有丝分裂原可能在淋巴细胞刺激中发挥重要作用。有人提出对T辅助细胞功能存在免疫遗传控制，至少有一种菌斑抗原与HLA - DR相关。这些反应可能通过某些菌斑成分的增强和抑制作用来调节，从而导致慢性局部炎症反应。
