Genua Marco, Rutella Sergio, Correale Carmen, Danese Silvio
IBD Center, Humanitas Clinical and Research Hospital, Rozzano, Italy.
Division of Translational Medicine, Research Branch, Sidra Medical & Research Center, Doha, Qatar.
J Transl Med. 2014 Oct 28;12:293. doi: 10.1186/s12967-014-0293-z.
The Triggering Receptors Expressed on Myeloid cells (TREM) are a family of cell-surface molecules that control inflammation, bone homeostasis, neurological development and blood coagulation. TREM-1 and TREM-2, the best-characterized receptors so far, play divergent roles in several infectious diseases. In the intestine, TREM-1 is highly expressed by macrophages, contributing to inflammatory bowel disease (IBD) pathogenesis. Contrary to current understanding, TREM-2 also promotes inflammation in IBD by fueling dendritic cell functions. This review will focus specifically on recent insights into the role of TREM proteins in IBD development, and discuss opportunities for novel treatment approaches.
髓系细胞表达的触发受体（TREM）是一类细胞表面分子家族，可控制炎症、骨稳态、神经发育和血液凝固。TREM-1和TREM-2是目前特征最明确的受体，在几种传染病中发挥着不同作用。在肠道中，巨噬细胞高度表达TREM-1，这有助于炎症性肠病（IBD）的发病机制。与目前的认识相反，TREM-2也通过促进树突状细胞功能在IBD中促进炎症。本综述将特别关注TREM蛋白在IBD发展中作用的最新见解，并讨论新型治疗方法的机会。
