Shevchenko R V, Litvin A A, Kolyvanov G B, Zherdev V P, Smirnov V V
Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia,
Bull Exp Biol Med. 2014 Oct;157(6):735-7. doi: 10.1007/s10517-014-2655-1. Epub 2014 Oct 29.
We studied pharmacokinetics of dilept after single cross-administration of tablets and substance of dilept in a dose of 40 mg to rabbits. The following pharmacokinetic parameters were calculated: maximum plasma concentration of dilept, time to maximum observed concentration, area under the pharmacokinetic curve, elimination half-life, and relative bioavailability. Dilept concentration in blood plasma was estimated using ultra-fast liquid chromatography with mass spectrometry detection. Relative bioavailability of dilept tablets was 93.46±28.91% of that for the substance.
我们研究了在给兔子单次交叉服用40毫克剂量的地来普特片剂和地来普特原料药后地来普特的药代动力学。计算了以下药代动力学参数：地来普特的最大血浆浓度、达到最大观察浓度的时间、药代动力学曲线下面积、消除半衰期和相对生物利用度。血浆中的地来普特浓度通过超快速液相色谱-质谱检测进行估算。地来普特片剂的相对生物利用度为原料药的93.46±28.91%。
