先兆流产中生殖激素抗体谱

Spectrum of antibodies to reproductive hormones in threatened abortion.

作者信息

Menzhinskaya I V, Van'ko L V, Kiryushchenkov P A, Tambovtseva M A, Kashentseva M M, Sukhikh G T

机构信息

V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of Russia, Moscow, Russia,

出版信息

Bull Exp Biol Med. 2014 Oct;157(6):747-50. doi: 10.1007/s10517-014-2658-y. Epub 2014 Oct 29.

DOI:10.1007/s10517-014-2658-y

PMID:25348563

Abstract

The spectrum of antibodies to reproductive hormones and the diagnostic significance of their measurements in threatened abortion during trimester I were studied. Enhanced production of antibodies to hormones was detected by ELISA in patients with threatened abortion (N=44) in comparison with women with normal gestation (N=30). These antibodies were detected more often than antiphospholipid antibodies (p<0.05). Antibodies to chorionic gonadotropin (IgM, IgG) and gonadotropin-releasing hormone (IgG) were associated with threatened abortion. According to ROC analysis, their measurements were diagnostically significant in this pathology (AUC>0.8). Subclasses IgG1 and IgG2 predominated among IgG to chorionic gonadotropin. Presumably, antibodies to chorionic gonadotropin and gonadotropin-releasing hormone could serve as independent factors of threatened abortion risk during trimester I.

摘要

研究了妊娠早期先兆流产患者生殖激素抗体谱及其检测的诊断意义。与正常妊娠女性（N = 30）相比，通过ELISA检测到先兆流产患者（N = 44）中激素抗体产生增强。这些抗体的检出率高于抗磷脂抗体（p<0.05）。绒毛膜促性腺激素抗体（IgM、IgG）和促性腺激素释放激素抗体（IgG）与先兆流产有关。根据ROC分析，它们的检测在这种病理情况下具有诊断意义（AUC>0.8）。绒毛膜促性腺激素IgG中IgG1和IgG2亚类占主导。推测绒毛膜促性腺激素抗体和促性腺激素释放激素抗体可能是妊娠早期先兆流产风险的独立因素。