J Cutan Med Surg. 2014 Nov;18(6):397-404. doi: 10.2310/7750.2014.13209.
Mucocutaneous manifestations of inflammatory bowel diseases are relatively common; the mean incidence is around 10% at the time of diagnosis. However, during follow-up, an increased variety of skin lesions, granulomatous cutaneous disease, reactive skin eruptions, nutritional defiencies, and other associated conditions may develop.
The objective of this study was to evaluate the prevalence of the mucocutaneous manifestations and their association with gender, duration of disease, arthritis, location of the bowel disease, and disease activity.
Fifty-six patients with ulcerative colitis (UC) and 36 patients with Crohn disease (CD) who were in follow-up in the Istanbul Medeniyet University Göztepe Training and Research Hospital Department of Gastroenterology were included in the study. Whole-body dermatologic examinations were performed for all patients, and patient files were evaluated for mucocutaneous manifestations.
Of the 92 patients, 49 (53.26%) presented with at least one mucocutaneous manifestation (58.9% of patients with UC and 44.4% of patients with CD). Of these, 38 (41.3%) had at least one reactive skin eruption. Aphthous stomatitis was noted in 33 patients (35.86%) and became the most common mucocutaneous manifestation. Granulomatous cutaneous diseases were detected in 18 patients (19.57%), and none of the patients had a nutritional deficiency-associated skin condition. Only 3 patients (3.26%) had erythema nodosum and 2 patients (2.17%) had pyoderma gangrenosum.
We found that mucocutaneous manifestations of inflammatory bowel diseases are more common than thought and are more common in UC than in CD. No association was detected between mucocutaneous manifestions and gender, duration of disease, arthritis, location of the bowel disease, and activity of the disease.
炎症性肠病的黏膜皮肤表现较为常见；在诊断时，其发病率约为 10%。然而，在随访过程中，可能会出现更多种类的皮肤损伤、肉芽肿性皮肤疾病、反应性皮肤疹、营养缺乏症和其他相关疾病。
本研究旨在评估黏膜皮肤表现的患病率及其与性别、疾病持续时间、关节炎、肠道疾病部位和疾病活动之间的关系。
本研究纳入了在伊斯坦布尔 Medeniyet 大学 Göztepe 培训与研究医院胃肠病科接受随访的 56 例溃疡性结肠炎（UC）患者和 36 例克罗恩病（CD）患者。对所有患者进行全身皮肤科检查，并评估患者病历中的黏膜皮肤表现。
在 92 例患者中，有 49 例（53.26%）至少存在一种黏膜皮肤表现（UC 患者为 58.9%，CD 患者为 44.4%）。其中，38 例（41.3%）至少存在一种反应性皮肤疹。口腔溃疡性口炎在 33 例患者（35.86%）中最为常见，成为最常见的黏膜皮肤表现。18 例患者（19.57%）被诊断为肉芽肿性皮肤疾病，且无患者存在与营养缺乏相关的皮肤疾病。仅有 3 例（3.26%）患者患有结节性红斑，2 例（2.17%）患者患有坏疽性脓皮病。
我们发现，炎症性肠病的黏膜皮肤表现比我们想象的更为常见，且在 UC 中比在 CD 中更为常见。我们未发现黏膜皮肤表现与性别、疾病持续时间、关节炎、肠道疾病部位和疾病活动之间存在关联。
