进展为慢性感染的成人急性乙型肝炎病毒感染患者的临床特征。

Clinical features of adult patients with acute hepatitis B virus infection progressing to chronic infection.

作者信息

Michitaka Kojiro, Hiraoka Atsushi, Tokumoto Yoshio, Ninomiya Keiko, Ninomiya Tomoyuki, Horiike Norio, Abe Masanori, Hiasa Yoichi

机构信息

Gastroenterology Center, Ehime Prefectural Central Hospital, Kasugamachi 83, Matsuyama, Ehime 790-0024, Japan.

Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon 791-0295, Japan.

出版信息

Int J Hepatol. 2014;2014:358206. doi: 10.1155/2014/358206. Epub 2014 Oct 2.

DOI:10.1155/2014/358206

PMID:25349743

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4202240/

Abstract

Background. Information regarding the progression of acute hepatitis B virus (HBV) infection to chronic infection in adults is scarce. Methods. Twenty-five adult patients with acute HBV infection (14 men and 11 women, 18-84 years old), whose clinical features progressed to those of chronic infection (group A) or did not (group B), were studied retrospectively. Results. There were 3 and 22 patients in groups A and B, respectively. Two of the 3 patients of group A lacked the typical symptoms of acute hepatitis. No differences were found between groups with respect to age, sex, or HBV genotypes. However, total bilirubin and alanine aminotransaminase levels were significantly lower in group A. Conclusions. Three of the 25 adult patients with acute HBV infection progressed to chronic infection. Hepatitis was mild in these patients. Patients with mild acute hepatitis B or unapparent HBV infection may have a higher risk of progressing to chronic infection.

摘要

背景。关于成人急性乙型肝炎病毒（HBV）感染进展为慢性感染的信息较少。方法。对25例急性HBV感染的成年患者（14例男性和11例女性，年龄18 - 84岁）进行回顾性研究，这些患者的临床特征进展为慢性感染（A组）或未进展为慢性感染（B组）。结果。A组和B组分别有3例和22例患者。A组的3例患者中有2例缺乏急性肝炎的典型症状。两组在年龄、性别或HBV基因型方面未发现差异。然而，A组的总胆红素和丙氨酸氨基转移酶水平显著较低。结论。25例急性HBV感染的成年患者中有3例进展为慢性感染。这些患者的肝炎病情较轻。轻度急性乙型肝炎或隐匿性HBV感染的患者进展为慢性感染的风险可能更高。