Thomsen Jakob Hartvig, Kjaergaard Jesper, Saust Laura Trolle, Wachtell Kristian, Hassager Christian
Hjertemedicinsk Klinik B, Hjertecentret, Rigshospitalet, Blegdamsvej 9, 2100 København Ø.
Ugeskr Laeger. 2014 Mar 17;176(12A).
Dabigatran has been approved for prevention of thromboembolic complications in nonvalvular atrial fibrillation. We present a case of thrombosis of a mechanical prosthetic mitral valve during anticoagulation with dabigatran, switched from warfarin. The patient presented with cardiogenic shock, was treated with thrombolytic therapy and discharged with warfarin therapy. Dabigatran in patients with mechanical valve prosthesis should be avoided and echocardiography is indicated if dyspnoea develops in such patients.
达比加群已被批准用于预防非瓣膜性心房颤动的血栓栓塞并发症。我们报告了1例在从华法林转换为达比加群抗凝治疗期间发生机械性人工二尖瓣血栓形成的病例。该患者出现心源性休克，接受了溶栓治疗，出院时接受华法林治疗。应避免在机械瓣膜置换患者中使用达比加群，此类患者若出现呼吸困难，应进行超声心动图检查。
