Jordon R E, Sell S
University of Texas Medical School, Houston.
Immunol Ser. 1989;46:109-22.
Thus the skin is a unique organ in terms of location. Our skin directly interfaces with our environment and thus, unlike any other organ, is constantly subjected to foreign substances and microorganisms. Many of its structures are unique, and many of the proteins expressed by epidermal cells are also unique. Exposure to ultraviolet light affects the expression of some of these proteins as well as other biochemical substances. Although the skin also functions as an immunologic organ, it is not surprising that it can be the subject of immunologic attack. Thus, all of the major humoral immune mechanisms, cytotoxic or cytolytic, immune complex and atopic or anaphylactic, are manifested in terms of skin diseases.
因此，就位置而言，皮肤是一个独特的器官。我们的皮肤直接与外界环境接触，因此，与其他任何器官不同，它不断接触外来物质和微生物。它的许多结构是独特的，表皮细胞表达的许多蛋白质也是独特的。紫外线照射会影响其中一些蛋白质以及其他生化物质的表达。尽管皮肤也作为一个免疫器官发挥作用，但它会成为免疫攻击的对象也就不足为奇了。因此，所有主要的体液免疫机制，即细胞毒性或细胞溶解、免疫复合物以及特应性或过敏性，都在皮肤病中有所体现。
