Department of Chemistry, University of Warwick , Coventry , UK ; Department of Basic Sciences, Turkish Military Academy , Ankara , Turkey.
School of Engineering and Materials Science, Queen Mary University of London , London , UK.
Front Bioeng Biotechnol. 2014 Oct 14;2:39. doi: 10.3389/fbioe.2014.00039. eCollection 2014.
Advances in the glycopolymer technology have allowed the preparation of more complex and well-defined glycopolymers/particles with several architectures from linear to globular structures (such as micelles, dendrimers, and nanogels). In the last decade, functionalized self-assembled/decided nano-objects and scaffolds containing glycopolymers were designed to develop many biological and biomedical applications in diseases treatments such as pathogen detection, inhibitors of toxins, and lectin-based biosensors. These studies will facilitate the understanding and investigation of the sugar code on the carbohydrate-lectin interactions, which are significantly influenced by the glycopolymer architecture, valency, size, and density of binding elements. In this context, these advanced and selected glycopolymers/particles showing specific interactions with various lectins are highlighted.
糖聚合物技术的进步使得能够制备更复杂和更明确的糖聚合物/颗粒,这些糖聚合物/颗粒具有多种结构,从线性到球形结构(如胶束、树枝状聚合物和纳米凝胶)。在过去的十年中,设计了功能化的自组装/决定的纳米物体和支架,其中包含糖聚合物,以开发许多在疾病治疗中的生物和生物医学应用,例如病原体检测、毒素抑制剂和基于凝集素的生物传感器。这些研究将促进对碳水化合物-凝集素相互作用中糖码的理解和研究,糖聚合物结构、价数、大小和结合元素密度显著影响碳水化合物-凝集素相互作用。在这种情况下,突出了这些与各种凝集素有特定相互作用的先进和精选的糖聚合物/颗粒。