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基于结构明确的糖聚物或糖纳米材料及其生物分子识别的糖聚物编码。

Glycopolymer code based on well-defined glycopolymers or glyconanomaterials and their biomolecular recognition.

机构信息

Department of Chemistry, University of Warwick , Coventry , UK ; Department of Basic Sciences, Turkish Military Academy , Ankara , Turkey.

School of Engineering and Materials Science, Queen Mary University of London , London , UK.

出版信息

Front Bioeng Biotechnol. 2014 Oct 14;2:39. doi: 10.3389/fbioe.2014.00039. eCollection 2014.

Abstract

Advances in the glycopolymer technology have allowed the preparation of more complex and well-defined glycopolymers/particles with several architectures from linear to globular structures (such as micelles, dendrimers, and nanogels). In the last decade, functionalized self-assembled/decided nano-objects and scaffolds containing glycopolymers were designed to develop many biological and biomedical applications in diseases treatments such as pathogen detection, inhibitors of toxins, and lectin-based biosensors. These studies will facilitate the understanding and investigation of the sugar code on the carbohydrate-lectin interactions, which are significantly influenced by the glycopolymer architecture, valency, size, and density of binding elements. In this context, these advanced and selected glycopolymers/particles showing specific interactions with various lectins are highlighted.

摘要

糖聚合物技术的进步使得能够制备更复杂和更明确的糖聚合物/颗粒,这些糖聚合物/颗粒具有多种结构,从线性到球形结构(如胶束、树枝状聚合物和纳米凝胶)。在过去的十年中,设计了功能化的自组装/决定的纳米物体和支架,其中包含糖聚合物,以开发许多在疾病治疗中的生物和生物医学应用,例如病原体检测、毒素抑制剂和基于凝集素的生物传感器。这些研究将促进对碳水化合物-凝集素相互作用中糖码的理解和研究,糖聚合物结构、价数、大小和结合元素密度显著影响碳水化合物-凝集素相互作用。在这种情况下,突出了这些与各种凝集素有特定相互作用的先进和精选的糖聚合物/颗粒。

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