State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.
J Am Chem Soc. 2014 Nov 12;136(45):15837-40. doi: 10.1021/ja5075745. Epub 2014 Nov 3.
An efficient palladium-catalyzed asymmetric hydrogenation via capture of an active intermediate generated in situ from acid-catalyzed aza-Pinacol rearrangement has been successfully developed, providing efficient access to chiral exocyclic amines with up to 98% ee. Three-, four-, and five-membered cyclic N-sulfonyl amino alcohols are viable substrates. This study opens a new window to the application of asymmetric hydrogenation.
一种高效的钯催化不对称氢化方法通过捕获原位生成的酸催化氮杂频哪醇重排的活性中间体来实现，该方法成功地提供了高效构建手性外消旋胺的途径，ee 值最高可达 98%。三种、四种和五种环状 N-磺酰基氨基醇是可行的底物。该研究为不对称氢化的应用开辟了新的窗口。
