Kivistö K, Nevalainen P, Lauronen L, Tupola S, Pihko E, Kivitie-Kallio S
a Department of Social Pediatrics , Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki , Helsinki , Finland .
b BioMag Laboratory , Hospital District of Helsinki and Uusimaa, HUS Medical Imaging Center, Helsinki University Central Hospital and University of Helsinki , Helsinki , Finland .
J Matern Fetal Neonatal Med. 2015;28(17):2015-9. doi: 10.3109/14767058.2014.978755. Epub 2014 Nov 11.
Opioid exposure during pregnancy is a potential risk factor for the developing central nervous system of the fetus. We studied evoked responses in buprenorphine-exposed newborns who displayed neonatal abstinence syndrome (NAS) to elucidate the possible alterations in functioning of the somatosensory and auditory systems.
We compared somatosensory (SEFs) and auditory evoked magnetic fields (AEFs), recorded with magnetoencephalography (MEG), of 11 prenatally buprenorphine-exposed newborns with those of 12 healthy newborns. Peak latencies, source strength and location of SEFs or AEFs were recorded.
AEFs were present in all buprenorphine-exposed newborns without significant differences from those of healthy newborns. In contrast, though no group level differences in SEFs existed, at individual level the response deviated from the typical neonatal morphology in four buprenorphine-exposed newborns.
Although buprenorphine exposure during pregnancy does not seem to cause constant deficiencies in somatosensory or auditory processing, in some newborns the typical development of somatosensory networks may be - at least transiently - disrupted.
孕期接触阿片类药物是胎儿中枢神经系统发育的一个潜在风险因素。我们研究了出现新生儿戒断综合征（NAS）的丁丙诺啡暴露新生儿的诱发反应，以阐明体感和听觉系统功能可能存在的改变。
我们将11名产前接触丁丙诺啡的新生儿与12名健康新生儿的体感诱发磁场（SEFs）和听觉诱发磁场（AEFs，通过脑磁图（MEG）记录）进行了比较。记录了SEFs或AEFs的峰潜伏期、源强度和位置。
所有丁丙诺啡暴露新生儿均存在AEFs，与健康新生儿相比无显著差异。相比之下，虽然SEFs在组水平上没有差异，但在个体水平上，4名丁丙诺啡暴露新生儿的反应偏离了典型的新生儿形态。
虽然孕期接触丁丙诺啡似乎不会导致体感或听觉处理持续存在缺陷，但在一些新生儿中，体感网络的典型发育可能至少会暂时受到干扰。
