Sagasta Amaia, Molina-Urra Ricardo, Martinez Daniel, Gonzalez-Farre Blanca, Marti Esther, Herranz Maria Jose, Estrach Teresa, Campo Elias, Colomo Lluis
Hematopathology Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain.
J Cutan Pathol. 2015 Jan;42(1):66-72. doi: 10.1111/cup.12409. Epub 2014 Dec 8.
A case of a 78-year-old woman with a CD8-positive peripheral T-cell lymphoma with aberrant expression of CD20 associated with follicular lymphoma in situ (FLIS) is reported. The neoplasm presented initially as cutaneous macules, papules, plaques and nodules. A skin biopsy was performed and the diagnosis of peripheral T-cell lymphoma (PTCl) with aberrant expression of CD20 was made. The staging procedures included an excisional inguinal lymph node biopsy that showed findings similar to those of the previous diagnosis. In addition, FLIS was identified. The clinicopathologic features of PTCLs with aberrant CD20 expression involving the skin as well as this uncommon association are reviewed.
报告了一例78岁女性，患有CD8阳性外周T细胞淋巴瘤，伴有与原位滤泡性淋巴瘤（FLIS）相关的CD20异常表达。该肿瘤最初表现为皮肤斑疹、丘疹、斑块和结节。进行了皮肤活检，诊断为CD20异常表达的外周T细胞淋巴瘤（PTCl）。分期程序包括切除腹股沟淋巴结活检，结果与先前诊断相似。此外，还发现了FLIS。本文回顾了皮肤受累且伴有异常CD20表达的PTCLs的临床病理特征以及这种罕见的关联。
