Watanabe Reiko, Okazaki Ryo
Third Department of Medicine, Teikyo University Chiba Medical Center, Japan.
Clin Calcium. 2014 Nov;24(11):1651-9.
Chronic obstructive pulmonary disease (COPD) , an inflammatory disease of the lung, is now recognized as a systemic disease because of various systemic comorbidities beyond lung. Osteoporosis is one of such major complications. The prevalence of vertebral fractures in COPD, especially at thoracic spine, is extremely high, however, pathophysiology of bone fragility in COPD is not well understood. COPD-associated osteoporosis impairs not only quality of life but also pulmonary function itself in COPD. Thus, timely intervention would be important, but only few COPD patients are treated for osteoporosis despite existing fractures mainly because of its low awareness among health-care providers. Measures should be taken to raise the awareness of COPD-associated osteoporosis along with the elucidation of its pathophysiology.
慢性阻塞性肺疾病（COPD）是一种肺部炎症性疾病，由于其存在肺部以外的各种全身性合并症，目前被认为是一种全身性疾病。骨质疏松症就是其中一种主要并发症。COPD患者椎体骨折的发生率极高，尤其是胸椎骨折，但COPD患者骨脆性的病理生理学尚未完全明确。COPD相关的骨质疏松症不仅会损害生活质量，还会影响COPD患者本身的肺功能。因此，及时干预很重要，但尽管存在骨折，仍只有少数COPD患者接受骨质疏松症治疗，主要原因是医疗保健人员对此认识不足。应采取措施提高对COPD相关骨质疏松症的认识，并阐明其病理生理学。
