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一例伴有Tk激活的血管外溶血病例。

A case of extravascular hemolysis with Tk-activation.

作者信息

Yamada Chisa, Davenport Robertson D

机构信息

Transfusion Medicine Division, Department of Pathology, University of Michigan Ann Arbor, Michigan.

出版信息

Clin Case Rep. 2014 Aug;2(4):137-42. doi: 10.1002/ccr3.80. Epub 2014 Jun 3.

DOI:10.1002/ccr3.80
PMID:25356271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4184649/
Abstract

A 50-year-old female with ovarian cancer for 4 years presented with abdominal pain. She started antibiotics for possible infection, and developed extravascular hemolysis. All antigen detection tests were negative, but lectin panel suggested Tk-activation. Additional laboratory testing in conjunction with blood bank is essential to investigate rare cause of hemolysis.

摘要

一名患有卵巢癌4年的50岁女性出现腹痛。她因可能的感染开始使用抗生素，并发生了血管外溶血。所有抗原检测试验均为阴性，但凝集素检测提示Tk激活。与血库联合进行额外的实验室检测对于调查溶血的罕见原因至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7088/4184649/ef09374267e3/ccr30002-0137-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7088/4184649/4c99e580c76e/ccr30002-0137-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7088/4184649/f3e45ce0e32f/ccr30002-0137-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7088/4184649/ef09374267e3/ccr30002-0137-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7088/4184649/4c99e580c76e/ccr30002-0137-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7088/4184649/f3e45ce0e32f/ccr30002-0137-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7088/4184649/ef09374267e3/ccr30002-0137-f3.jpg

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本文引用的文献

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Life-threatening piperacillin-induced immune haemolysis in a patient with cystic fibrosis.一名囊性纤维化患者发生了危及生命的哌拉西林诱导的免疫性溶血。
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Piperacillin-induced immune hemolysis presenting with tachycardia and cardiac arrest.哌拉西林诱导的免疫性溶血伴心动过速和心脏骤停。
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Pathology consultation on drug-induced hemolytic anemia.药物诱导性溶血性贫血的病理咨询。
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Piperacillin-induced immune hemolytic anemia in an adult with cystic fibrosis.哌拉西林诱发的成年囊性纤维化患者免疫性溶血性贫血。
Case Rep Med. 2010;2010:161454. doi: 10.1155/2010/161454. Epub 2010 Jun 2.
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Transfusion. 2010 May;50(5):1135-8. doi: 10.1111/j.1537-2995.2009.02544.x. Epub 2009 Dec 29.
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T activation.T 激活。
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