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Post-traumatic bone and/or joint limb infections due to Clostridium spp.创伤后梭菌属引起的骨和/或关节肢体感染
Orthop Traumatol Surg Res. 2012 Oct;98(6):696-705. doi: 10.1016/j.otsr.2012.03.019. Epub 2012 Aug 27.
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Pre-emptive treatment for Clostridium tetani: importance of early recognition and treatment in the community.破伤风梭菌的预防性治疗:社区中早期识别与治疗的重要性
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.03.2009.1649. Epub 2009 Jun 11.
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RNAmmer: consistent and rapid annotation of ribosomal RNA genes.RNAmmer:核糖体RNA基因的一致性快速注释
Nucleic Acids Res. 2007;35(9):3100-8. doi: 10.1093/nar/gkm160. Epub 2007 Apr 22.
4
The genome sequence of Clostridium tetani, the causative agent of tetanus disease.破伤风病的病原体破伤风梭菌的基因组序列。
Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1316-21. doi: 10.1073/pnas.0335853100. Epub 2003 Jan 27.
5
TetR is a positive regulator of the tetanus toxin gene in Clostridium tetani and is homologous to botR.TetR是破伤风梭菌中破伤风毒素基因的正调控因子,与botR同源。
Infect Immun. 1998 Dec;66(12):5698-702. doi: 10.1128/IAI.66.12.5698-5702.1998.
6
tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.tRNAscan-SE:用于改进基因组序列中转运RNA基因检测的程序。
Nucleic Acids Res. 1997 Mar 1;25(5):955-64. doi: 10.1093/nar/25.5.955.

一株引起慢性骨炎的破伤风梭菌的基因组

Genome of a chronic osteitis-causing Clostridium tetani.

作者信息

Fournier P-E, Levy P-Y, Million M, Croce O, Blanc-Tailleur C, Brouqui P, Raoult D

机构信息

Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, INSERM U1095, Institut Hospitalo-Universitaire Méditerranée Infection, Faculté de Médecine, Aix-Marseille Université 27 Boulevard Jean Moulin, 13005, Marseille, France ; Fédération de Microbiologie, Centre Hospitalier Universitaire de La Timone 264 Rue Saint Pierre, 13005, Marseille, France.

Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, INSERM U1095, Institut Hospitalo-Universitaire Méditerranée Infection, Faculté de Médecine, Aix-Marseille Université 27 Boulevard Jean Moulin, 13005, Marseille, France ; Service de Maladies Infectieuses, Hôpital Nord AP-HM, Chemin des Bourrely, 13013, Marseille, France.

出版信息

New Microbes New Infect. 2014 Jan;2(1):25-6. doi: 10.1002/2052-2975.27. Epub 2014 Jan 28.

DOI:10.1002/2052-2975.27
PMID:25356334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4184619/
Abstract

We sequenced the genome of a Clostridium tetani strain that caused chronic tibial osteitis without any clinical sign of tetanus in a 26-year-old man previously vaccinated against this disease. The genome contained a plasmid that harboured the tetX-tetR tetanospasmin operon, and was highly similar to that of a tetanus-causing strain.

摘要

我们对一株破伤风梭菌的基因组进行了测序,该菌株在一名先前接种过破伤风疫苗的26岁男性身上引发了慢性胫骨骨髓炎,但没有任何破伤风的临床症状。该基因组包含一个携带tetX-tetR破伤风痉挛毒素操纵子的质粒,并且与一株导致破伤风的菌株的基因组高度相似。