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顺铂化疗胆管癌后无低钠血症的桥外髓鞘溶解相关可逆性小脑共济失调

Reversible Cerebellar Ataxia Related to Extrapontine Myelinolysis without Hyponatremia after Cisplatin-Based Chemotherapy for Cholangiocarcinoma.

作者信息

Chung Jae Heun, Baik Seung Kug, Cho Su-Hee, Kim Seong-Geun

机构信息

Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.

Department of Diagnostic Radiology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.

出版信息

Cancer Res Treat. 2015 Apr;47(2):329-33. doi: 10.4143/crt.2013.145. Epub 2014 Sep 11.

DOI:10.4143/crt.2013.145
PMID:25358385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4398115/
Abstract

A 60-year-old woman presented with cerebellar signs including dysarthria and ataxia, after intravenous infusion of cisplatin-based chemotherapy. Several blood tests showed mild neutropenia, normocytic normochromic anemia, but no evidence of a marked hyponatremia. Brain magnetic resonance imaging with diffusion-weighted sequences showed hyper-intense signal abnormalities in the extrapontine region, sparing the basis pontis. Here, we report on the case of a patient with reversible cerebellar ataxia related to extrapontine myelinolysis without hyponatremia after treatment with cisplatin-based chemotherapy for cholangiocarcinoma and discuss the literature on cerebellar ataxia in patients who underwent recent chemotherapy for malignancy.

摘要

一名60岁女性在静脉输注基于顺铂的化疗药物后出现小脑体征，包括构音障碍和共济失调。多项血液检查显示轻度中性粒细胞减少、正细胞正色素性贫血，但无明显低钠血症的证据。脑磁共振成像弥散加权序列显示脑桥外区域有高强度信号异常，脑桥基底部未受累。在此，我们报告一例胆管癌患者在接受基于顺铂的化疗后出现与脑桥外髓鞘溶解相关的可逆性小脑共济失调且无低钠血症的病例，并讨论近期接受恶性肿瘤化疗患者小脑共济失调的相关文献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/4398115/1a0e651cd19b/crt-2013-145f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/4398115/beba5d8eccab/crt-2013-145f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/4398115/1a0e651cd19b/crt-2013-145f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/4398115/beba5d8eccab/crt-2013-145f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/4398115/1a0e651cd19b/crt-2013-145f2.jpg

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本文引用的文献

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Value of diffusion-weighted imaging in central pontine and extrapontine myelinolysis.弥散加权成像在脑桥中央和脑桥外髓鞘溶解症中的价值。
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