Fischer S, Kueckelhaus M, Pauzenberger R, Bueno E M, Pomahac B
Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Hand-, Plastic and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany.
Am J Transplant. 2015 Jan;15(1):220-33. doi: 10.1111/ajt.12956. Epub 2014 Oct 30.
In this study we provide a compilation of functional impairments before and improvements after face transplantation (FT) of five FT recipients of our institution and all FTs reported in current literature. Functional outcome included the ability to smell, breath, eat, speak, grimace and facial sensation. Before FT, all our patients revealed compromised ability to breath, eat, speak, grimace and experience facial sensation. The ability to smell was compromised in two of our five patients. Two patients were dependent on tracheostomy and one on gastrostomy tubes. After FT, all abilities were significantly improved and all patients were independent from artificial air airways and feeding tubes. Including data given in current literature about the other 24 FT recipients in the world, the abilities to smell, eat and feel were enhanced in 100% of cases, while the abilities of breathing, speaking and facial expressions were ameliorated in 93%, 71% and 76% of cases, respectively. All patients that required gastrostomy and 91% of patients depending on tracheostomy were decannulated after FT. Unfortunately, outcomes remain unreported in all other cases and therefore we are unable to comment on improvements.
在本研究中,我们汇总了我院5例面部移植(FT)受者面部移植前后的功能损伤情况以及当前文献中报道的所有面部移植案例。功能结果包括嗅觉、呼吸、进食、说话、做鬼脸和面部感觉的能力。面部移植前,我们所有患者的呼吸、进食、说话、做鬼脸及面部感觉能力均受损。5例患者中有2例嗅觉受损。2例患者依赖气管造口术,1例依赖胃造瘘管。面部移植后,所有能力均显著改善,所有患者均不再依赖人工气道和喂食管。纳入当前文献中关于全球其他24例面部移植受者的数据后发现,嗅觉、进食和感觉能力在100%的病例中得到增强,而呼吸、说话和面部表情能力分别在93%、71%和76%的病例中得到改善。所有需要胃造瘘术的患者以及91%依赖气管造口术的患者在面部移植后均拔除了导管。遗憾的是,所有其他案例的结果均未报道,因此我们无法对改善情况进行评论。