Yilmaz Özgür, Calan Mehmet, Kume Tuncay, Temur Muzaffer, Yesil Pınar, Senses Mehmet Y
Department of Obstetrics and Gynecology, Manisa Merkezefendi State Hospital, Inciralti, Turkey; Department of Obstetrics and Gynecology, Manisa Akhisar State Hospital, Inciralti, Turkey.
Clin Endocrinol (Oxf). 2015 May;82(5):747-52. doi: 10.1111/cen.12647. Epub 2014 Dec 4.
Polycystic ovary syndrome (PCOS) is associated with cardiovascular risk factors including hypertension, obesity, hyperlipidaemia and glucose intolerance. Several studies demonstrated the link between PCOS and an increased risk of cardiovascular disease. Platelets play a crucial role in the development of atherothrombotic disease. Mean platelet volume (MPV) is a marker of platelet size that reflects its activity. Research points to a link between prolactin (PRL) and platelet activation. The purpose of this study was to investigate whether prolactin levels are associated with MPV in women with PCOS.
The research was designed as a cross-sectional study.
Participants were divided into three groups-PCOS patients with mildly elevated PRL levels (n = 72), patients with PCOS with normal PRL levels (n = 207) and healthy controls (n = 90). They were body mass index and age-matched and consecutively recruited.
Complete blood counts, serum glucose, prolactin, insulin, lipids, high-sensitivity C-reactive protein and free-testosterone levels were measured.
Among the three groups, MPV levels were higher in women with PCOS having mildly elevated PRL levels (P < 0·001) and MPV was found to be correlated with PRL levels (r = 0·387, P < 0·001). Multiple regression analysis showed that PRL levels were associated with MPV levels (R(2) = 0·239, β = 0·354, P < 0·001).
Mean platelet volume levels are significantly increased in women with PCOS having mildly elevated PRL. Our results suggest that there is a link between prolactin and MPV levels. In women with PCOS, elevated PRL levels may increase the risk of developing atherothrombotic events via the activation of platelets.
多囊卵巢综合征（PCOS）与包括高血压、肥胖、高脂血症和葡萄糖不耐受在内的心血管危险因素相关。多项研究证实了PCOS与心血管疾病风险增加之间的联系。血小板在动脉粥样硬化血栓形成疾病的发展中起关键作用。平均血小板体积（MPV）是反映血小板活性的血小板大小标志物。研究表明催乳素（PRL）与血小板活化之间存在联系。本研究的目的是调查PCOS女性的催乳素水平是否与MPV相关。
本研究设计为横断面研究。
参与者分为三组——PRL水平轻度升高的PCOS患者（n = 72）、PRL水平正常的PCOS患者（n = 207）和健康对照者（n = 90）。他们按体重指数和年龄匹配，并连续招募。
检测全血细胞计数、血清葡萄糖、催乳素、胰岛素、血脂、高敏C反应蛋白和游离睾酮水平。
在三组中，PRL水平轻度升高的PCOS女性的MPV水平较高（P < 0·001），且发现MPV与PRL水平相关（r = 0·387，P < 0·001）。多元回归分析表明PRL水平与MPV水平相关（R(2) = 0·239，β = 0·354，P < 0·001）。
PRL轻度升高的PCOS女性的平均血小板体积水平显著升高。我们的结果表明催乳素与MPV水平之间存在联系。在PCOS女性中，升高的PRL水平可能通过激活血小板增加发生动脉粥样硬化血栓形成事件的风险。
