Enderling Heiko
Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Integr Biol (Camb). 2015 Jan;7(1):14-23. doi: 10.1039/c4ib00191e.
Central to the debate about cancer stem cells in solid tumors is the proportion of cells that can initiate, propagate, and re-initiate tumors. An initially assumed minor subpopulation is confronted with recent data suggesting as many as 30% of primary tumor cells have stem cell characteristics. This review discusses quantitative modeling studies that augment our understanding of stem and non-stem cancer cell interactions during tumor progression and the resulting fraction of cancer stem cells. A discussion of how these findings can be carefully evaluated in novel, integrated interdisciplinary studies is offered.
实体瘤中癌症干细胞的争论核心在于能够启动、增殖和重新启动肿瘤的细胞比例。最初假定的一小部分亚群面临着最近的数据，这些数据表明多达30%的原发性肿瘤细胞具有干细胞特征。本综述讨论了定量建模研究，这些研究增进了我们对肿瘤进展过程中干细胞与非干细胞癌细胞相互作用以及由此产生的癌症干细胞比例的理解。本文还讨论了如何在新颖的、综合的跨学科研究中仔细评估这些发现。
