Taormina David P, Shulman Brandon S, Karia Raj, Spitzer Allison B, Konda Sanjit R, Egol Kenneth A
Department of Orthopaedic Surgery, Hospital for Joint Diseases at NYU Langone Medical Center, New York, NY, USA.
Department of Orthopaedic Surgery, George Washington University Hospital, Washington, DC, USA.
Geriatr Orthop Surg Rehabil. 2014 Sep;5(3):116-21. doi: 10.1177/2151458514532811.
Elderly patients are at risk of fracture nonunion, given the potential setting of osteopenia, poorer fracture biology, and comorbid medical conditions. Risk factors predicting fracture nonunion may compromise the success of fracture nonunion surgery. The purpose of this study was to investigate the effect of patient age on clinical and functional outcome following long bone fracture nonunion surgery.
A retrospective analysis of prospectively collected data identified 288 patients (aged 18-91) who were indicated for long bone nonunion surgery. Two-hundred and seventy-two patients satisfied study inclusion criteria and analyses were performed comparing elderly patients aged ≥65 years (n = 48) with patients <65 years (n = 224) for postoperative wound complications, Short Musculoskeletal Functional Assessment (SMFA) functional status, healing, and surgical revision. Regression analyses were performed to look for associations between age, smoking status, and history of previous nonunion surgery with healing and functional outcome. Twelve-month follow-up was obtained on 91.5% (249 of 272) of patients.
Despite demographic differences in the aged population, including a predominance of medical comorbidities (P < .01) and osteopenia (P = .02), there was no statistical differences in the healing rate of elderly patients (95.8% vs 95.1%, P = .6) or time to union (6.2 ± 4.1 months vs. 7.2 ± 6.6, P = .3). Rates of postoperative wound complications and surgical revision did not statistically differ. Elderly patients reported similar levels of function up to 12 months after surgery. Regression analyses failed to show any significant association between age and final union or time to union. There was a strong positive association between smoking and history of previous nonunion surgery with time to union. Age was associated (positively) with 12-month SMFA activity score.
Smoking and failure of previous surgical intervention were associated with nonunion surgery outcomes. Patient's age at the time of surgery was not associated with achieving union. Advanced age was generally not associated with poorer nonunion surgery outcomes.
鉴于存在骨质减少、骨折生物学特性较差以及合并内科疾病的潜在情况,老年患者有骨折不愈合的风险。预测骨折不愈合的危险因素可能会影响骨折不愈合手术的成功率。本研究的目的是调查患者年龄对长骨骨折不愈合手术后临床和功能结局的影响。
对前瞻性收集的数据进行回顾性分析,确定了288例(年龄18 - 91岁)适合长骨不愈合手术的患者。272例患者符合研究纳入标准,对年龄≥65岁的老年患者(n = 48)与年龄<65岁的患者(n = 224)进行分析,比较术后伤口并发症、短肌肉骨骼功能评估(SMFA)功能状态、愈合情况及手术翻修情况。进行回归分析以寻找年龄、吸烟状况以及既往不愈合手术史与愈合和功能结局之间的关联。对91.5%(272例中的249例)的患者进行了12个月的随访。
尽管老年人群在人口统计学方面存在差异,包括内科合并症占优势(P <.01)和骨质减少(P =.02),但老年患者的愈合率(95.8%对95.1%,P =.6)或愈合时间(6.2±4.1个月对7.2±6.6个月,P =.3)无统计学差异。术后伤口并发症和手术翻修率在统计学上无差异。老年患者在术后长达12个月时报告的功能水平相似。回归分析未显示年龄与最终愈合或愈合时间之间存在任何显著关联。吸烟以及既往不愈合手术史与愈合时间之间存在强正相关。年龄与12个月时的SMFA活动评分呈正相关。
吸烟和既往手术干预失败与不愈合手术结局相关。手术时患者的年龄与实现愈合无关。高龄通常与较差的不愈合手术结局无关。