与印度围产期感染儿童中HIV进展缓慢相关的遗传因素。
Genetic factors associated with slow progression of HIV among perinatally-infected Indian children.
作者信息
Chaudhuri Riya Pal, Neogi Ujjwal, Rao Shwetha D, Shet Anita
机构信息
Departments *Clinical Virology, #Hematology Research Unit, Microbiology and Department of Pediatrics, St. John's Medical College Hospital, Bangalore, India. Correspondence to: Dr Anita Shet, Department of Pediatrics, St. Johns Medical College Hospital, Bangalore 560 034, India.
出版信息
Indian Pediatr. 2014 Oct;51(10):801-3. doi: 10.1007/s13312-014-0505-x.
OBJECTIVE
To study the association between common AIDS restriction genes and slow disease progression among perinatally-infected children in India.
METHODS
ART-naïve children were identified and selected host factors including CCR5-∆32, SDF1-3'A, CCR5-59029G, HLA-B27, B57 were studied using allele-specific PCR-RFLP and SSPGo HLA typing kits.
RESULTS
Among 165 children, 10 (6%) long-term non-progressors and 8 (5%) slow progressors were identified. For comparison, 12 children with normal progression of HIV were included. The frequencies of CCR5-∆32 deletion, SDF1-3'A and CCR5-59029G did not differ significantly. HLA-B27 and B57 were observed only in long-term non-progressors or slow progressors, who also harbored either SDF1-3'A and/or CCR5-59029G.
CONCLUSIONS
There is an association between host genetic factors and slow disease progression in this population.
目的
研究印度围产期感染儿童中常见艾滋病限制基因与疾病进展缓慢之间的关联。
方法
识别出未接受抗逆转录病毒治疗的儿童，并使用等位基因特异性聚合酶链反应-限制性片段长度多态性（PCR-RFLP）和序列特异性引物-凝胶电泳（SSPGo）HLA分型试剂盒研究包括CCR5-∆32、SDF1-3'A、CCR5-59029G、HLA-B27、B57在内的宿主因素。
结果
在165名儿童中，识别出10名（6%）长期无进展者和8名（5%）疾病进展缓慢者。作为对照，纳入了12名HIV病情正常进展的儿童。CCR5-∆32缺失、SDF1-3'A和CCR5-59029G的频率无显著差异。仅在长期无进展者或疾病进展缓慢者中观察到HLA-B27和B57，这些儿童还携带SDF1-3'A和/或CCR5-59029G。
结论
该人群中宿主遗传因素与疾病进展缓慢之间存在关联。
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