Dhivyalakshmi Jeevarathnam, Bhattacharyya Shaila, Reddy Rajeshwari, Arulselvi K I
Departments of Pediatric Endocrinology and *Pediatrics, Manipal Hospital, Bengaluru, India. Correspondence to: Dr J Dhivyalakshmi, C/o Dr. A. Karunagaran, 60/39, Model Hutment Road, CIT Nagar, Nandanam, Chennai 600 035, Tamilnadu, India.
Indian Pediatr. 2014 Oct;51(10):831-3.
It is important to differentiate central from peripheral causes of precocious puberty because of distinct management options.
4 girls with discordant pubertal development.
All had low basal and GnRHa stimulated FSH and LH level with high estradiol level. Abdominal ultrasonogram helped in diagnosing precocious pseudopuberty- ovarian cyst in 3 children and juvenile granulosa cell tumour in one.
Case 1 and 4 underwent surgery in view of persistent cyst and tumor, respectively. Rest were managed conservatively. Regression of pubertal signs observed in all children during follow-up.
Precocious pseudopuberty can be differentiated from central precocious puberty by GnRHa Stimulation test, bone age and abdominal ultrasound.
