Eguchi Hisashi, Shimazu Akihito, Kawakami Norito, Inoue Akiomi, Nakata Akinori, Tsutsumi Akizumi
Department of Public Health, Kitasato University School of Medicine, 1-15-1, Kitasato, Minami, Sagamihara, 252-0374, Japan,
Int Arch Occup Environ Health. 2015 Aug;88(6):651-8. doi: 10.1007/s00420-014-0995-9. Epub 2014 Nov 2.
Evidence on the association between psychological well-being and high-sensitivity C-reactive protein (hs-CRP) levels is limited. We carried out a prospective study to investigate the association between work engagement and hs-CRP levels in a group of Japanese workers.
Our cohort included 1,857 men and 657 women aged 65 and under, and free from major illness, working at two manufacturing worksites in Japan. Baseline examinations were conducted from April to June 2011 to determine the demographic and lifestyle characteristics and levels of work engagement. Blood samples were obtained from participants at baseline and after 1 year. Participants were classified into tertiles of low, moderate, and high work engagement at baseline. Hs-CRP levels were split into low (≤3.0 mg/L) and high (>3.0 mg/L). We used multiple logistic regression analyses to evaluate the association between work engagement at baseline and hs-CRP levels at follow-up, adjusting for hs-CRP at baseline and potential confounding factors.
Participants reporting moderate and high levels of work engagement at baseline had significantly lower odds ratios (ORs) of having high hs-CRP levels at follow-up than those with low levels of work engagement at baseline [OR of moderate level 0.44, 95% confidence interval (CI) 0.24-0.81; OR of high level 0.57, 95% CI 0.33-0.99; p for trend <0.05].
Findings suggest that work engagement has beneficial effects on workers' cardiovascular health.
关于心理健康与高敏C反应蛋白(hs-CRP)水平之间关联的证据有限。我们开展了一项前瞻性研究,以调查一组日本工人的工作投入与hs-CRP水平之间的关联。
我们的队列包括1857名65岁及以下的男性和657名女性,他们无重大疾病,在日本的两个制造工作场所工作。于2011年4月至6月进行基线检查,以确定人口统计学和生活方式特征以及工作投入水平。在基线时和1年后从参与者身上采集血样。在基线时将参与者分为低、中、高工作投入三分位数组。hs-CRP水平分为低(≤3.0mg/L)和高(>3.0mg/L)。我们使用多元逻辑回归分析来评估基线时的工作投入与随访时的hs-CRP水平之间的关联,并对基线时的hs-CRP和潜在混杂因素进行了调整。
在基线时报告工作投入水平为中等和高的参与者在随访时hs-CRP水平高的优势比(OR)显著低于基线时工作投入水平低的参与者[中等水平的OR为0.44,95%置信区间(CI)为0.24-0.81;高水平的OR为0.57,95%CI为0.33-0.99;趋势p<0.05]。
研究结果表明,工作投入对工人的心血管健康有有益影响。