IFI16基因多态性影响HIV-1感染中的CD4(+) T细胞计数。
Polymorphism in IFI16 affects CD4(+) T-cell counts in HIV-1 infection.
作者信息
Booiman T, Kootstra N A
机构信息
Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory and Center for Infection and Immunity (CINIMA), Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.
出版信息
Int J Immunogenet. 2014 Dec;41(6):518-20. doi: 10.1111/iji.12157. Epub 2014 Nov 3.
Interferon-γ-inducible protein 16 (IFI16) plays a pivotal role in the death of bystander CD4(+) T-cells. Here, we demonstrate that SNP rs1417806 in IFI16 is associated with CD4(+) T-cell counts at set point and HIV-1 disease progression, indicating that IFI16 affects HIV-1 pathogenesis especially during the early phase of infection.
干扰素γ诱导蛋白16（IFI16）在旁观者CD4(+) T细胞死亡中起关键作用。在此，我们证明IFI16中的单核苷酸多态性rs1417806与设定点时的CD4(+) T细胞计数及HIV-1疾病进展相关，表明IFI16尤其在感染早期影响HIV-1发病机制。
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