Oda Eiji
Medical Check-up Center, Tachikawa Medical Center, Japan.
Intern Med. 2014;53(21):2463-9. doi: 10.2169/internalmedicine.53.1998. Epub 2014 Nov 1.
There have been no previous studies regarding the relationship between the respiratory function and incident diabetes in East Asian women in whom obesity is not prevalent.
Using Cox regression models, hazard ratios (HRs) for incident diabetes for each one SD increase in the percent vital capacity (%VC), a parameter of restrictive pulmonary dysfunction, forced expiratory volume in one second over forced vital capacity (FEV1/FVC), a parameter of obstructive pulmonary dysfunction, and log high-sensitivity C-reactive protein (hs-CRP) were calculated in 1,704 men and 1,016 women among a Japanese health screening population.
Over the four-year study period (mean of 3.4 years), 54 men (3.2%) and 19 women (1.9%) developed diabetes. The HRs [95% confidence intervals (CIs); p values] for incident diabetes for each one SD increase in %VC and log hs-CRP were 0.81 (0.61-1.06; 0.127) and 1.29 (0.97-1.73; 0.085), respectively in men, and 0.55 (0.35-0.88) 0.012 and 2.50 (1.37-4.57; 0.003), respectively in women adjusted for age, fasting glucose and body mass index. The FEV1/FVC was not found to be significantly associated with incident diabetes in any regression models. The Spearman's correlation coefficients between %VC and hs-CRP was -0.11 (p<0.001) in men and -0.08 (p=0.007) in women. The HRs (95% CIs; p values) for each one SD increase in %VC and hs-CRP were 0.86 (0.65-1.13; 0.278) and 1.26 (0.94-1.70; 0.125), respectively in men, and 0.56 (0.34-0.94; 0.028) and 2.95 (1.49-5.81; 0.002), respectively in women, further adjusted for each other, systolic blood pressure, triglycerides and HDL cholesterol.
A low %VC was found to be associated with incident diabetes, independent of hs-CRP in women among a Japanese health screening population.
此前尚无关于肥胖并不普遍的东亚女性呼吸功能与新发糖尿病之间关系的研究。
在日本健康筛查人群中的1704名男性和1016名女性中，使用Cox回归模型计算了限制性肺功能障碍参数肺活量百分比（%VC）每增加一个标准差、阻塞性肺功能障碍参数一秒用力呼气容积与用力肺活量之比（FEV1/FVC）以及高敏C反应蛋白（hs-CRP）对数每增加一个标准差时新发糖尿病的风险比（HRs）。
在为期四年的研究期间（平均3.4年），54名男性（3.2%）和19名女性（1.9%）患糖尿病。在根据年龄、空腹血糖和体重指数进行调整后，男性中%VC和hs-CRP对数每增加一个标准差时新发糖尿病的HRs[95%置信区间（CIs）；p值]分别为0.81（0.61 - 1.06；0.127）和1.29（0.97 - 1.73；0.085），女性中分别为0.55（0.35 - 0.88；0.012）和2.50（1.37 - 4.57；0.003）。在任何回归模型中均未发现FEV1/FVC与新发糖尿病有显著关联。男性中%VC与hs-CRP之间的Spearman相关系数为-0.11（p<0.001），女性中为-0.08（p = 0.007）。在进一步根据彼此、收缩压、甘油三酯和高密度脂蛋白胆固醇进行调整后，男性中%VC和hs-CRP每增加一个标准差时的HRs（95% CIs；p值）分别为0.86（0.65 - 1.13；0.278）和1.26（0.94 - 1.70；0.125），女性中分别为0.56（0.34 - 0.94；0.028）和2.95（1.49 - 日）。
在日本健康筛查人群的女性中，发现低%VC与新发糖尿病相关，且独立于hs-CRP。
