Tamai Koji, Tachikawa Ryo, Otsuka Kyoko, Ueda Hiroyuki, Hosono Yuji, Tomii Keisuke
Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Japan.
Intern Med. 2014;53(21):2515-9. doi: 10.2169/internalmedicine.53.2769. Epub 2014 Nov 1.
We herein report a patient with clinically amyopathic dermatomyositis (CADM) who developed anti-CADM-140 autoantibody in association with rapidly progressive interstitial lung disease (RP-ILD). Chest high-resolution computed tomography (HRCT) revealed early pulmonary involvement preceding typical cutaneous lesions. Primary lesions of patchy peribronchial opacity developed ground-glass opacity and consolidation with architectural distortion and traction bronchiectasis. The possibility of anti-CADM-140 autoantibody-associated RP-ILD should be considered when patchy peribronchial opacity of an unknown cause is visible on chest HRCT.
我们在此报告一名临床无肌病性皮肌炎（CADM）患者，其出现抗CADM - 140自身抗体并伴有快速进展性间质性肺病（RP - ILD）。胸部高分辨率计算机断层扫描（HRCT）显示在典型皮肤病变之前就有早期肺部受累。斑片状支气管周围模糊影的原发性病变发展为磨玻璃影，并伴有结构扭曲和牵拉性支气管扩张的实变。当胸部HRCT上可见原因不明的斑片状支气管周围模糊影时，应考虑抗CADM - 140自身抗体相关的RP - ILD的可能性。
