Zhang Dawei, Ding Yuanyuan, Wang Zhenlin, Wang Yan, Zhao Guangyue
Department of Orthopedics, Xi Jing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Tumour Biol. 2015 Mar;36(3):1791-5. doi: 10.1007/s13277-014-2781-4. Epub 2014 Nov 4.
A T>G single nucleotide polymorphism (SNP, rs2279744) of the MDM2 gene has been investigated in sarcoma community, but the findings are conflicting. This study was designed to well define the relationship between SNP rs2279744 and sarcoma risk. We did a systematic computerized search of the PubMed, Web of Science, and Science Direct databases to identify the human case-control studies investigating the relationship between SNP rs2279744 and sarcoma risk with complete genetic data. Pooled odds ratios (ORs) were calculated with the Mantel-Haenszel fixed-effect model or the DerSimonian and Laird random effects model to estimate the risk of sarcoma. Overall analysis included five independent studies. On the whole, the T/G genotype or the combined G/G and T/G genotypes appeared to be associated with approximately 1.40-fold higher risk of sarcoma relative to the T/T genotype (T/G vs. T/T: OR 1.33, 95% CI 1.00-1.77; G/G + T/G vs. T/T: OR 1.42, 95% CI 1.08-1.85). We noted that the Caucasian populations showed a similarly increased risk of sarcoma ascribed to the carriage of the same genotypes (T/G vs. T/T: OR 1.41, 95% CI 1.05-1.90; G/G + T/G vs. T/T: OR 1.49, 95% CI 1.13-1.97). This meta-analysis provides evidence that MDM2 SNP rs2279744 may be significantly associated with increased risk of sarcoma in Caucasian individuals.
MDM2基因的一个T>G单核苷酸多态性（SNP，rs2279744）已在肉瘤领域进行了研究，但结果相互矛盾。本研究旨在明确SNP rs2279744与肉瘤风险之间的关系。我们对PubMed、科学网和科学Direct数据库进行了系统的计算机检索，以识别研究SNP rs2279744与肉瘤风险关系且具有完整基因数据的人类病例对照研究。采用Mantel-Haenszel固定效应模型或DerSimonian和Laird随机效应模型计算合并比值比（OR），以估计肉瘤风险。总体分析包括五项独立研究。总体而言，相对于T/T基因型，T/G基因型或G/G与T/G合并基因型似乎与肉瘤风险高约1.40倍相关（T/G与T/T比较：OR 1.33，95%CI 1.00-1.77；G/G + T/G与T/T比较：OR 1.42，95%CI 1.08-1.85）。我们注意到，白种人群中，相同基因型的携带也显示出类似的肉瘤风险增加（T/G与T/T比较：OR 1.41，95%CI 1.05-1.90；G/G + T/G与T/T比较：OR 1.49，95%CI 1.13-1.97）。这项荟萃分析提供了证据，表明MDM2 SNP rs2279744可能与白种人个体肉瘤风险增加显著相关。
