骨关节炎：膝关节和髋关节骨关节炎中关节软骨的表观遗传学 - Suppr

Osteoarthritis: Epigenetics of articular cartilage in knee and hip OA.

作者信息

Loughlin John, Reynard Louise N

机构信息

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, 4th Floor Catherine Cookson Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

出版信息

Nat Rev Rheumatol. 2015 Jan;11(1):6-7. doi: 10.1038/nrrheum.2014.189. Epub 2014 Nov 4.

DOI:10.1038/nrrheum.2014.189

PMID:25366188

Abstract

摘要

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Epigenetic differences in human cartilage between mild and severe OA.

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Genome-wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage.

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CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis susceptibility SNP rs143383.

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Osteoarthritis: Epigenetics of articular cartilage in knee and hip OA.

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