Kloog Y, Ambar I, Kochva E, Wollberg Z, Bdolah A, Sokolovsky M
Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel.
FEBS Lett. 1989 Jan 2;242(2):387-90. doi: 10.1016/0014-5793(89)80507-1.
Sarafotoxin-b, a potent snake vasoconstrictor peptide homologous to the mammalian endothelial vasoconstrictor endothelin, induces phosphoinositide (PI) hydrolysis in various brain regions of the rat. Sarafotoxin-b induced PI hydrolysis is largely independent of extracellular Ca2+ and is detected in all brain regions where toxin-binding sites are found. These results point to the existence of a hitherto undetected neuroreceptor associated with the PI cycle.
萨拉弗毒素 -b是一种与哺乳动物内皮血管收缩因子内皮素同源的强效蛇类血管收缩肽，可诱导大鼠不同脑区的磷酸肌醇（PI）水解。萨拉弗毒素 -b诱导的PI水解在很大程度上不依赖细胞外Ca2+，并且在所有发现毒素结合位点的脑区均能检测到。这些结果表明存在一种迄今未被发现的与PI循环相关的神经受体。
