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The gene for catalase is assigned between the antigen loci MIC4 and MIC11.

作者信息

Couillin P, Azoulay M, Metezeau P, Grisard M C, Junien C

机构信息

Génétique et Pathologie foetale, INSERM U. 73, Château de Longchamp, Paris, France.

出版信息

Genomics. 1989 Jan;4(1):7-11. doi: 10.1016/0888-7543(89)90307-8.

Abstract

Genetic analysis of the cells of a WAGR patient (W, predisposition to Wilms tumor; A, aniridia; G, genitourinary abnormalities; R, mental retardation), bearing a partial deletion of band 11p13, was performed with biochemical and antigenic 11p markers by using gene dosage, somatic hybridization, molecular hybridization, and indirect immunofluorescence techniques. These studies allowed the regional assignment of the gene for catalase, which is linked to the Wilms tumor locus, between MIC4 and MIC11, two loci encoding for membrane antigens previously mapped to band 11p13.

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