过氧化氢酶基因定位于抗原基因座MIC4和MIC11之间。
The gene for catalase is assigned between the antigen loci MIC4 and MIC11.
作者信息
Couillin P, Azoulay M, Metezeau P, Grisard M C, Junien C
机构信息
Génétique et Pathologie foetale, INSERM U. 73, Château de Longchamp, Paris, France.
出版信息
Genomics. 1989 Jan;4(1):7-11. doi: 10.1016/0888-7543(89)90307-8.
Genetic analysis of the cells of a WAGR patient (W, predisposition to Wilms tumor; A, aniridia; G, genitourinary abnormalities; R, mental retardation), bearing a partial deletion of band 11p13, was performed with biochemical and antigenic 11p markers by using gene dosage, somatic hybridization, molecular hybridization, and indirect immunofluorescence techniques. These studies allowed the regional assignment of the gene for catalase, which is linked to the Wilms tumor locus, between MIC4 and MIC11, two loci encoding for membrane antigens previously mapped to band 11p13.
对一名患有WAGR综合征（W，易患肾母细胞瘤；A，无虹膜；G，泌尿生殖系统异常；R，智力迟钝）且11p13带部分缺失的患者的细胞进行了遗传分析，采用基因剂量、体细胞杂交、分子杂交和间接免疫荧光技术，利用生化和抗原性11p标记物进行检测。这些研究确定了过氧化氢酶基因的区域定位，该基因与肾母细胞瘤基因座相关，位于MIC4和MIC11之间，这两个基因座编码先前定位到11p13带的膜抗原。
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