Marbacher Serge, Fathi Ali Reza, Muroi Carl, Coluccia Daniel, Andereggen Lukas, Neuschmelting Volker, Widmer Hans Rudolf, Jakob Stephan M, Fandino Javier
Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland,
Acta Neurochir Suppl. 2015;120:337-42. doi: 10.1007/978-3-319-04981-6_58.
The recently introduced rabbit blood shunt subarachnoid haemorrhage model is based on the two standard procedures of subclavian artery cannulation and transcutaneous cisterna magna puncture. An extracorporeal shunt placed in between the arterial system and the subarachnoid space allows examiner-independent SAH in a closed cranium. Despite its straightforwardness, it is worth examining some specific features and characteristics of the model. We outline technical considerations to successfully perform the model with minimal mortality and morbidity. In addition, we discuss outcome measures, advantages and limitations, and the applicability of the model for the study of early brain injury and delayed cerebral vasospasm after SAH.
最近引入的兔血分流蛛网膜下腔出血模型基于锁骨下动脉插管和经皮枕大池穿刺这两种标准程序。置于动脉系统和蛛网膜下腔之间的体外分流装置可在封闭颅骨内实现与检查者无关的蛛网膜下腔出血。尽管该模型操作简单，但仍值得研究其一些特定特征。我们概述了技术要点，以便以最低的死亡率和发病率成功实施该模型。此外，我们还讨论了结果指标、优缺点以及该模型在蛛网膜下腔出血后早期脑损伤和迟发性脑血管痉挛研究中的适用性。
