Liu Jianxing, Chen Pan, Guo Meihua, Lu Lechun, Li Lihua
School of Forensic Medicine, Kunming Medical University, No. 1168 West Chunrong Road, Yuhua Avenue, Chenggong District, Kunming, 650500, Yunnan, People's Republic of China.
Neurol Sci. 2015 Apr;36(4):621-3. doi: 10.1007/s10072-014-1998-8. Epub 2014 Nov 4.
In previous study, we have found the catechol-O-methyltransferase (COMT) Val158Met polymorphism may be associated with the risk of Parkinson's disease (PD) in Asians, especially Japanese population. In this study, we further evaluated the associations of PD wearing-off susceptibility with COMT polymorphisms. We carried out a retrieval of studies and included the relevant studies which met the criteria. After the data were extracted, the Stata software 11.0 was used to analyse the genotype frequencies. A total of five studies were included. The pooled result indicated that genotype AA was significantly associated with the wearing-off risk of PD (AA vs. others: OR = 2.52, 95 % CI 1.21-5.26, P = 0.013; AA vs. GA: OR = 2.51, 95 % CI 1.18-5.34, P = 0.017; AA vs. GG: OR = 2.17, 95 % CI 1.09-4.33, P = 0.027). The results also showed allele A was correlated with PD wearing-off risk (A vs. G: OR = 1.95, 95 % CI 1.18-3.22, P = 0.009). In conclusion, this study suggested that Val158Met polymorphisms in COMT may increase the risk of wearing-off. Further studies with larger sample sizes are needed to confirm our results.
在之前的研究中，我们发现儿茶酚-O-甲基转移酶（COMT）基因Val158Met多态性可能与亚洲人，尤其是日本人群患帕金森病（PD）的风险相关。在本研究中，我们进一步评估了COMT基因多态性与PD剂末现象易感性之间的关联。我们进行了文献检索，并纳入了符合标准的相关研究。数据提取后，使用Stata软件11.0分析基因型频率。共纳入五项研究。汇总结果表明，基因型AA与PD剂末现象风险显著相关（AA与其他基因型比较：OR = 2.52，95%CI 1.21 - 5.26，P = 0.013；AA与GA比较：OR = 2.51，95%CI 1.18 - 5.34，P = 0.017；AA与GG比较：OR = 2.17，95%CI 1.09 - 4.33，P = 0.027）。结果还显示，等位基因A与PD剂末现象风险相关（A与G比较：OR = 1.95，95%CI 1.18 - 3.22，P = 0.009）。总之，本研究表明COMT基因中的Val158Met多态性可能增加剂末现象的风险。需要进一步开展更大样本量的研究来证实我们的结果。
