多模式理念下的肝切除术可提高转移性黑色素瘤患者的生存率：一项单中心病例匹配对照研究
Liver resection in multimodal concepts improves survival of metastatic melanoma: a single-centre case-matched control study.
作者信息
Hau Hans Michael, Tautenhahn Hans-Michael, Schoenberg Markus Bo, Atanasov Georgi, Wiltberger Georg, Morgül Mehmet Haluk, Uhlmann Dirk, Seitz Anna Theresa, Simon Jan C, Schmelzle Moritz, Bartels Michael
机构信息
Department of Visceral, Transplant, Vascular and Thoracic Surgery, University Hospital of Leipzig, Leipzig, Germany.
Department of Visceral, Transplant, Vascular and Thoracic Surgery, University Hospital of Leipzig, Leipzig, Germany
出版信息
Anticancer Res. 2014 Nov;34(11):6633-9.
BACKGROUND/AIM: The aim of the present study was to define prognostic factors and to evaluate liver resection as an additive tool in metastatic melanoma.
PATIENTS AND METHODS
In a case-control study, 32 patients with hepatic melanoma metastasis were analyzed between 1998-2012. Sixteen patients who underwent liver resection (6 patients with multimodal therapy) were matched to 16 patients scheduled for non-surgical approaches. Univariate and multivariate analyses were performed.
RESULTS
Following primary resection and liver resection, respectively, survival was better for patients who underwent surgery in addition to multimodal therapy with 219 and 28 months, when compared to patients scheduled for non-surgical approaches with 64 (p=0.04) and 8 months (p=0.6). Following primary resection, primary tumor site, metastatic time <70 months, combination of multimodal therapy and surgery were of prognostic value (p<0.05).
CONCLUSION
Liver resection should be considered a suitable additive tool in multimodal therapy of resectable metastatic melanoma.
背景/目的：本研究的目的是确定预后因素，并评估肝切除术作为转移性黑色素瘤综合治疗手段的作用。
患者与方法
在一项病例对照研究中，对1998年至2012年间32例发生肝转移的黑色素瘤患者进行分析。16例行肝切除术的患者（6例接受多模式治疗）与16例计划采用非手术治疗的患者进行匹配。进行单因素和多因素分析。
结果
分别在初次切除和肝切除后，接受多模式治疗加手术的患者生存期较好，分别为219个月和28个月，相比之下，计划采用非手术治疗的患者生存期分别为64个月（p = 0.04）和8个月（p = 0.6）。初次切除后，原发肿瘤部位、转移时间<70个月、多模式治疗与手术联合应用具有预后价值（p<0.05）。
结论
肝切除术应被视为可切除转移性黑色素瘤多模式治疗中合适的辅助手段。
Zotero 插件