Farsi Leila, Afshari Khashayar, Keshavarz Mansoor, NaghibZadeh Maryam, Memari Fereidoon, Norouzi-Javidan Abbas
aBrain and Spinal Cord Injury Research Center bElectrophysiology Research Center, Neuroscience Institute cDepartment of Physiology, School of Medicine dCancer Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Behav Pharmacol. 2015 Apr;26(3):315-20. doi: 10.1097/FBP.0000000000000103.
Spinal cord injury (SCI) has a number of severe and disabling consequences including chronic pain. Approximately 40% of patients experience neuropathic pain, which appears to be persistent. Previous studies have demonstrated the neuroprotective effects of magnesium sulfate (MgSO4). We aimed to investigate the effect of MgSO4 on neuropathic pains following SCI in male rats. Thirty-two adult male rats (weight 300-350 g) were used. After laminectomy, a complete SCI was induced by compression of the spinal cord for 1 min with an aneurysm clip. A single dose of 300 or 600 mg/kg MgSO4 was injected intraperitoneally. Tail-flick latency and acetone drop test scores were evaluated before surgery and once a week for 4 weeks after surgery. Rats in groups SCI+Mg300 and SCI+Mg600 showed significantly higher mean tail-flick latencies and lower mean scores in the acetone test compared with those in the SCI+veh group 4 weeks after surgery (P<0.05). These findings revealed that systemic single-dose administration of MgSO4 can attenuate thermal hyperalgesia and cold allodynia induced by SCI in rats.
脊髓损伤（SCI）会导致许多严重且使人致残的后果，包括慢性疼痛。约40%的患者会经历神经性疼痛，且这种疼痛似乎具有持续性。先前的研究已证实硫酸镁（MgSO4）具有神经保护作用。我们旨在研究MgSO4对雄性大鼠脊髓损伤后神经性疼痛的影响。使用了32只成年雄性大鼠（体重300 - 350克）。椎板切除术后，用动脉瘤夹压迫脊髓1分钟诱导完全性脊髓损伤。腹腔注射单剂量300或600毫克/千克的MgSO4。在手术前以及术后4周每周评估一次甩尾潜伏期和丙酮滴注试验评分。术后4周，SCI + Mg300组和SCI + Mg600组大鼠的平均甩尾潜伏期显著更长，丙酮试验中的平均评分更低，与SCI + 赋形剂组相比差异有统计学意义（P < 0.05）。这些研究结果表明，全身单剂量给予MgSO4可减轻大鼠脊髓损伤诱导的热痛觉过敏和冷觉异常。
