Faculty of Tourism and Recreation, Gdansk University of Physical Education and Sport, Kazimierza Gorskiego Street 1, 80-336 Gdansk, Poland.
Faculty of Physical Education and Health Promotion, University of Szczecin, Piastow 40B, 71-065 Szczecin, Poland.
PPAR Res. 2014;2014:373782. doi: 10.1155/2014/373782. Epub 2014 Oct 13.
Peroxisome proliferator-activated receptor γ is a key regulator of adipogenesis, responsible for fatty acid storage and maintaining energy balance in the human body. Studies on the functional importance of the PPARG Pro12Ala polymorphic variants indicated that the observed alleles may influence body mass measurements; however, obtained results were inconsistent. We have decided to check if body mass changes observed in physically active participants will be modulated by the PPARG Pro12Ala genotype. The genotype distribution of the PPARG Pro12Ala allele was examined in a group of 201 Polish women measured for selected body mass variables before and after the completion of a 12-week training program. The results of our experiment suggest that PPARG genotype can modulate training-induced body mass measurements changes: after completion of the training program, Pro12/Pro12 homozygotes were characterised by a greater decrease of body fat mass measurements in comparison with 12Ala allele carriers. These results indicate that the PPARG 12Ala variant may impair the training-induced positive effects on body mass measurements; however, the detailed mechanism of such interaction remained unclear and observed correlation between PPARG genotype and body mass differential effects should be interpreted with caution.
过氧化物酶体增殖物激活受体 γ 是脂肪生成的关键调节因子，负责储存脂肪酸并维持人体的能量平衡。对 PPARG Pro12Ala 多态性变异体的功能重要性的研究表明，观察到的等位基因可能会影响体重测量值；然而，所得结果并不一致。我们决定检查在积极进行体育锻炼的参与者中，观察到的体重变化是否会受到 PPARG Pro12Ala 基因型的调节。在一项对 201 名波兰女性进行的研究中，检查了 PPARG Pro12Ala 等位基因的基因型分布，这些女性在完成 12 周的训练计划前后测量了选定的体重变量。我们的实验结果表明，PPARG 基因型可以调节训练引起的体重测量变化：在完成训练计划后，Pro12/Pro12 纯合子的体脂量测量值比 12Ala 等位基因携带者下降更大。这些结果表明，PPARG 12Ala 变体可能会损害训练引起的对体重测量的积极影响；然而，这种相互作用的详细机制尚不清楚，并且应该谨慎解释 PPARG 基因型与体重差异效应之间的观察到的相关性。
