Geetha N, Shahid Abdul, Rajan Varun, Jacob Priya Mary
Department of Medical Oncology, Regional Cancer Centre, Trivandrum 695011, India.
Department of Pathology, Regional Cancer Centre, Trivandrum 695011, India.
Ecancermedicalscience. 2014 Sep 25;8:466. doi: 10.3332/ecancer.2014.466. eCollection 2014.
Primary renal lymphoma is a rare entity representing less than 1% of lesions in the kidney. We present the case of a 42-year-old male who was evaluated for pain and a mass in the abdomen. The computed tomogram of the abdomen showed a large lobulated homogeneously enhancing mass lesion of about 14×12×18 cm, involving the whole of the left kidney and encasing the left renal vessels and ureter. The patient underwent a biopsy, and the histopathology was diffuse large B cell lymphoma, positive for LCA, CD20, PAX 5, Bcl 2 and negative for SIgM, CD33, CD34, CD5, Tdt, with MIB 1 labelling index of 40%. He received chemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R CHOP) for eight cycles followed by radiation to the residual mass and achieved complete remission. Currently, he is alive and in remission at 28 months.
原发性肾淋巴瘤是一种罕见的疾病,在肾脏病变中所占比例不到1%。我们报告一例42岁男性病例,该患者因腹部疼痛和肿块接受评估。腹部计算机断层扫描显示一个大约14×12×18 cm的大的分叶状均匀强化肿块病变,累及整个左肾,并包绕左肾血管和输尿管。患者接受了活检,组织病理学检查为弥漫性大B细胞淋巴瘤,LCA、CD20、PAX 5、Bcl 2阳性,SIgM、CD33、CD34、CD5、Tdt阴性,MIB 1标记指数为40%。他接受了8个周期的利妥昔单抗、环磷酰胺、阿霉素、长春新碱和泼尼松龙(R-CHOP)化疗,随后对残留肿块进行放疗,实现了完全缓解。目前,他在28个月时仍存活且处于缓解状态。