Vandewalle B, Lefebvre J
Laboratoire d'Endocrinologie Expérimentale, Centre Oscar Lambret, Lille, France.
Mol Cell Endocrinol. 1989 Feb;61(2):239-46. doi: 10.1016/0303-7207(89)90135-4.
Catecholestrogens and especially 2-hydroxyestrone (2OH-E1) are estradiol metabolites locally formed in breast cancer cells. The present study demonstrates that the two parent compounds, estradiol (E2) and its metabolite 2OH-E1, exert opposite effects on hormone-sensitive breast cancer cell growth assessed by cell counts and transferrin receptor levels, and also on cell differentiation assessed by secreted proteins such as alpha-lactalbumin and gross cystic disease fluid protein (GCDFP-15). The present findings may highlight estradiol regulation in hormone-sensitive breast cancer cells.
儿茶酚雌激素，尤其是2-羟基雌酮（2OH-E1）是在乳腺癌细胞中局部形成的雌二醇代谢产物。本研究表明，两种母体化合物，即雌二醇（E2）及其代谢产物2OH-E1，对通过细胞计数和转铁蛋白受体水平评估的激素敏感性乳腺癌细胞生长具有相反的作用，对通过分泌蛋白如α-乳白蛋白和乳腺囊肿病液体蛋白（GCDFP-15）评估的细胞分化也具有相反的作用。本研究结果可能突出了激素敏感性乳腺癌细胞中的雌二醇调节作用。
