具有非常规配对模式的人工碱基对三磷酸酯的简短直接合成。
Short and straightforward synthesis of triphosphates of artificial nucleobase pairs displaying unconventional pairing scheme.
作者信息
Kore Anilkumar R, Yang Bo, Srinivasan Balasubramanian
机构信息
a Bioorganic Chemistry Division , Life Sciences Solutions Group, Thermo Fisher Scientific , Austin , TX , USA.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2014;33(12):767-73. doi: 10.1080/15257770.2014.938754.
PMID:25372992
Abstract
Concise, facile and efficient synthesis of 5'-O-triphosphates of 6-amino-5-nitro-3-(1'-β-D-2'-deoxyribofuranosyl)-2(1H)-pyridone (dZ) and its Watson-Crick complement 2-amino-8-(1'-β-D-2'-deoxyribofuranosyl)-imidazo[1,2a]-1,3,5-triazin-4(8H)-one (dP) is reported using a one-pot synthetic procedure.
摘要
报道了采用一锅合成法简洁、简便且高效地合成6-氨基-5-硝基-3-(1'-β-D-2'-脱氧呋喃核糖基)-2(1H)-吡啶酮(dZ)及其沃森-克里克互补物2-氨基-8-(1'-β-D-2'-脱氧呋喃核糖基)-咪唑并[1,2a]-1,3,5-三嗪-4(8H)-酮(dP)的5'-O-三磷酸酯。
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