Zheng Yue, Sintim Herman O
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
Chem Biol. 2014 Oct 23;21(10):1261-1263. doi: 10.1016/j.chembiol.2014.10.001.
The article by Gerdt and colleagues in this issue of Chemistry & Biology provides molecular insights into how nonlactone quorum sensing modulators either activate or deactivate LasR. Interestingly, an antagonist could flip into an agaonist upon mutation of a single residue in the autoinducer binding site.
格特及其同事在本期《化学与生物学》上发表的文章，提供了关于非内酯群体感应调节剂如何激活或失活LasR的分子见解。有趣的是，在自诱导物结合位点的单个残基发生突变后，拮抗剂可能会转变为激动剂。
