Zhou Xin, Wang Xiaping, Huang Zebo, Xu Lei, Zhu Wei, Liu Ping
Department of Oncology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.
Key Laboratory of Human Functional Genomics of Jiangsu Province, Clinical Diabetes Centre of Jiangsu Province, Nanjing Medical University, Nanjing, 210029, China.
J Exp Clin Cancer Res. 2014 Nov 6;33(1):94. doi: 10.1186/s13046-014-0094-5.
Breast cancer patients with positive estrogen receptor (ER) have a better prognosis. However, no prognostic miRNA signature was reported in the ER-positive breast cancer. The aim of the study was to identify and assess the prognostic significance of a miRNA signature in ER-positive breast cancer.
Two cohorts from The Cancer Genome Atlas (TCGA) dataset were used as training (n =596) and testing set (n =319). Differential expression profiling was identified in the training set. And the prognostic value of the miRNA signature was then assessed in the two cohorts.
A total of 14 miRNAs were observed to be associated with the status of ER by significance analysis of microarrays (SAM) in the training set. Patients were characterized as high score or low score group according to the calculated risk scores from each miRNA. And patients in high score group had worse overall survival compared with those in low score group both in the training and testing set.
Our study revealed a miRNA signature including 14 miRNAs associated with ER status which could act as a prognostic marker in ER-positive breast cancer.
雌激素受体（ER）阳性的乳腺癌患者预后较好。然而，尚未有关于ER阳性乳腺癌的预后性miRNA特征报道。本研究的目的是鉴定并评估ER阳性乳腺癌中一种miRNA特征的预后意义。
来自癌症基因组图谱（TCGA）数据集的两个队列分别用作训练集（n = 596）和测试集（n = 319）。在训练集中鉴定差异表达谱。然后在这两个队列中评估miRNA特征的预后价值。
通过训练集中的微阵列显著性分析（SAM），共观察到14种miRNA与ER状态相关。根据每个miRNA计算的风险评分，将患者分为高分或低分两组。在训练集和测试集中，高分患者组的总生存期均比低分患者组差。
我们的研究揭示了一种包含14种与ER状态相关的miRNA特征，其可作为ER阳性乳腺癌的预后标志物。
