90天壬基酚暴露对成年雄性大鼠的精子发生和精子成熟有不良影响。
90d Exposure to Nonylphenol has Adverse Effects on the Spermatogenesis and Sperm Maturation of Adult Male Rats.
作者信息
Lu Wei Chen, Wang Ai Qing, Chen Xiao Ling, Yang Guo, Lin Yao, Chen Yi Ou, Hong Cheng Jiao, Tian Hai Lin
机构信息
Department of Occupational and Environmental Health, School of Public Health, Soochow University, Suzhou 215123, Jiangsu, China; KunShan Health Inspection Station, 458 Tongfeng Road, Kunshan 215301, Jiangsu, China.
Experimental Center of Medical College, Soochow University, Suzhou 215123, Jiangsu, China.
出版信息
Biomed Environ Sci. 2014 Nov;27(11):907-11. doi: 10.3967/bes2014.128.
This study was conducted to elucidate the reproductive effect of NP on testis, epididymis and epididymal sperm in vivo. Adult male Sprague-Dawley rats were gavaged with NP at 0, 40, 100, or 250 mg/kg body weight (bw) on alternate days for 90 d. The results showed that oral administration of NP may damage the structure and function of testis, induce apoptosis and oxidative stress in epididymis or even have cytotoxic effects on epididymal sperm.
本研究旨在阐明纳米颗粒（NP）对体内睾丸、附睾及附睾精子的生殖影响。将成年雄性斯普拉格-道利大鼠每隔一天按0、40、100或250毫克/千克体重灌胃纳米颗粒，持续90天。结果表明，口服纳米颗粒可能损害睾丸的结构和功能，诱导附睾细胞凋亡和氧化应激，甚至对附睾精子产生细胞毒性作用。
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