Wang Ruozheng, Tan Yao, Wang Xiyan, Ma Lingling, Wang Duoming, Hu Yunhui, Qin Yonghui, Liu Kai, Chang Cheng, Yu Jinming
Tianjin Medical University, Tianjing, People's Republic of China; Department of Radiation Oncology, The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, People's Republic of China.
Department of Radiation Oncology, The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, People's Republic of China.
PLoS One. 2014 Nov 6;9(11):e111145. doi: 10.1371/journal.pone.0111145. eCollection 2014.
The objective of this study was to investigate the long-term outcomes and prognostic factors for nasopharyngeal carcinoma (NPC) in Han and Uyghur patients treated with intensity-modulated radiotherapy (IMRT) in the Xinjiang region of China.
One hundred twenty-one Han and 60 Uyghur patients with newly diagnosed NPC without distant metastasis received IMRT at the Affiliated Tumor Hospital of Xinjiang Medical University between 2005 and 2008. The Kaplan-Meier method was used to estimate survival rates, and the log-rank test was used to evaluate differences in survival.
Comparing Han and Uyghur patients, the 5-year overall survival (OS), disease-free survival (DFS), local control (LC), regional control (RC), and distant metastasis-free survival (DMFS) rates were 81.9% vs 77.6% (P = 0.297), 72.1% vs 65.6% (P = 0.493), 88.3% vs 86.5% (P = 0.759), 95.0% vs 94.6% (P = 0.929), and 79.1% vs 75.2% (P = 0.613), respectively. Multivariate Cox proportional hazards regression identified the following independent prognostic factors in Han patients: N stage (P = 0.007) and age (P = 0.028) for OS, and age (P = 0.028) for DFS. OS differed significantly between Han and Uyghur patients >60 years old group (P = 0.036). Among Uyghur patients, the independent prognostic factors were age for OS (P = 0.033), as well as N stage (P = 0.037) and age (P = 0.021) for DFS. Additionally, Uyghur patients were less likely to experience mucositis and dermatitis than Han patients.
Han and Uyghur patients with NPC had statistically significant differences in age, smoking history, and N staging. There was no significant difference in overall treatment outcomes with IMRT between these 2 ethnic populations in Xinjiang, China.
本研究旨在调查中国新疆地区接受调强放射治疗（IMRT）的汉族和维吾尔族鼻咽癌（NPC）患者的长期预后及预后因素。
2005年至2008年期间，121例汉族和60例维吾尔族新诊断的无远处转移的NPC患者在新疆医科大学附属肿瘤医院接受了IMRT治疗。采用Kaplan-Meier法估计生存率，采用对数秩检验评估生存差异。
比较汉族和维吾尔族患者，5年总生存率（OS）、无病生存率（DFS）、局部控制率（LC）、区域控制率（RC）和无远处转移生存率（DMFS）分别为81.9%对77.6%（P = 0.297）、72.1%对65.6%（P = 0.493）、88.3%对86.5%（P = 0.759）、95.0%对94.6%（P = 0.929）和79.1%对75.2%（P = 0.613）。多因素Cox比例风险回归分析确定汉族患者的以下独立预后因素：OS的N分期（P = 0.007）和年龄（P = 0.028），DFS的年龄（P = 0.028）。60岁以上汉族和维吾尔族患者的OS有显著差异（P = 0.036）。在维吾尔族患者中，OS的独立预后因素是年龄（P = 0.033），DFS的独立预后因素是N分期（P = 0.037）和年龄（P = 0.021）。此外，维吾尔族患者发生黏膜炎和皮炎的可能性低于汉族患者。
汉族和维吾尔族NPC患者在年龄、吸烟史和N分期方面存在统计学显著差异。在中国新疆的这两个民族群体中，IMRT的总体治疗结果无显著差异。
