Department of IT Convergence, Korea National University of Transportation, Chungju 380-702, Republic of Korea.
Nanoscale. 2014 Dec 21;6(24):15196-202. doi: 10.1039/c4nr04805a. Epub 2014 Nov 6.
Water soluble fluorescent carbon nanoparticles (FCP) obtained from a single natural source, mango fruit, were developed as unique materials for non-toxic bio-imaging with different colors and particle sizes. The prepared FCPs showed blue (FCP-B), green (FCP-G) and yellow (FCP-Y) fluorescence, derived by the controlled carbonization method. The FCPs demonstrated hydrodynamic diameters of 5-15 nm, holding great promise for clinical applications. The biocompatible FCPs demonstrated great potential in biological fields through the results of in vitro imaging and in vivo biodistribution. Using intravenously administered FCPs with different colored particles, we precisely defined the clearance and biodistribution, showing rapid and efficient urinary excretion for safe elimination from the body. These findings therefore suggest the promising possibility of using natural sources for producing fluorescent materials.
从单一天然来源——芒果果实中提取的水溶性荧光碳纳米粒子（FCP），被开发为具有不同颜色和粒径的无毒生物成像的独特材料。通过控制碳化法，制备的 FCP 呈现蓝色（FCP-B）、绿色（FCP-G）和黄色（FCP-Y）荧光。FCP 的水动力直径为 5-15nm，具有很大的临床应用前景。通过体外成像和体内生物分布的结果，生物相容性 FCP 展示了在生物领域的巨大潜力。使用不同颜色颗粒的静脉内给予的 FCP，我们精确地定义了清除和生物分布，显示出快速和有效的尿液排泄，以安全地从体内消除。因此，这些发现表明使用天然资源生产荧光材料具有广阔的前景。
