Li Cui-ling, Zhao Kai, Li Hui, Farah Omar Ibrahim, Wang Jiao-jiao, Sun Rong-ze, Zhang Hui-ping
Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of Science and Technology Service, Hubei Provincial Population and Family Planning Commission, Wuhan, Hubei, China.
PLoS One. 2014 Nov 6;9(11):e111918. doi: 10.1371/journal.pone.0111918. eCollection 2014.
This work aims to collect and summarize the outcomes on free preconceptual screening examination in rural areas of Hubei Province in 2012. Moreover, this review promotes further understanding of the status of this activity to provide the Family Planning Commission valid scientific data upon which to construct effective policies.
Couples, who complied with the family planning policy and were the residents in agricultural areas or lived in a local rural area for more than six months, were encouraged to participate in the free preconceptual screening examination service provided by the Hubei Provincial Population and Family Planning Commission. This service included 19 screening tests. All the data, including forms, manuals, and test results, were collected from 1 January 2012 to 31 December 2012 in rural areas in Hubei Province.
A total of 497,860 individuals participated in the free preconceptual screening examination service, with a coverage rate of 97.1%. 4.0% and 4.8% of the participants exhibited with abnormal blood levels of ALT and creatinine, respectively; 0.36% of the participants tested positive for syphilis; 0.44% and 3.6% of the female participants tested positive for Neisseria gonorrhoeae and Chlamydia trachomatis, respectively; and 0.84% and 1.8% of the female participants tested positive for cytomegalovirus (IgM) and Toxoplasma gondii (IgM), respectively. After risk assessment, 59,935 participants might have high-risk of adverse pregnancy outcomes. In 2012, the prevalence of birth defects among the parturient who participated in the preconceptual screening examination service was 0.04%, while the prevalence was 0.08% among those who did not participate in the service.
Preconceptual screening examination service may help to address the risk factors that can lead to adverse pregnancy outcome. More studies on the relationship between preconceptual screening examination service and prevalence of birth defect or other adverse pregnancy outcomes should be conducted.
本研究旨在收集并总结2012年湖北省农村地区免费孕前筛查检查的结果。此外，本综述有助于进一步了解该活动的开展情况，为计划生育委员会制定有效政策提供有效的科学数据。
鼓励符合计划生育政策、为农村地区居民或在当地农村居住超过六个月的夫妇参加湖北省人口和计划生育委员会提供的免费孕前筛查检查服务。该服务包括19项筛查测试。所有数据，包括表格、手册和检测结果，均于2012年1月1日至12月31日在湖北省农村地区收集。
共有497,860人参加了免费孕前筛查检查服务，覆盖率为97.1%。分别有4.0%和4.8%的参与者谷丙转氨酶和肌酐血液水平异常；0.36%的参与者梅毒检测呈阳性；分别有0.44%和3.6%的女性参与者淋病奈瑟菌和沙眼衣原体检测呈阳性；分别有0.84%和1.8%的女性参与者巨细胞病毒（IgM）和弓形虫（IgM）检测呈阳性。经过风险评估，59,935名参与者可能有不良妊娠结局的高风险。2012年，参加孕前筛查检查服务的产妇出生缺陷患病率为0.04%，而未参加该服务的产妇患病率为0.08%。
孕前筛查检查服务可能有助于解决导致不良妊娠结局的风险因素。应进一步开展关于孕前筛查检查服务与出生缺陷患病率或其他不良妊娠结局之间关系的研究。
