脉冲染料激光治疗婴幼儿血管瘤：系统评价和荟萃分析。
Pulsed dye laser therapy for infantile hemangiomas: a systemic review and meta-analysis.
机构信息
From the Department of Oral Maxillofacial-Head Neck Oncology, Laser&Cosmetic Center, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China, VIP Department, Stomatology Hospital of Shandong University, Jinan, China and Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University, Shanghai, China From the Department of Oral Maxillofacial-Head Neck Oncology, Laser&Cosmetic Center, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China, VIP Department, Stomatology Hospital of Shandong University, Jinan, China and Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
From the Department of Oral Maxillofacial-Head Neck Oncology, Laser&Cosmetic Center, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China, VIP Department, Stomatology Hospital of Shandong University, Jinan, China and Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
出版信息
QJM. 2015 Jun;108(6):473-80. doi: 10.1093/qjmed/hcu206. Epub 2014 Nov 4.
BACKGROUND
Infantile hemangiomas (IH) are common pediatric tumors. This meta-analysis was performed to review the therapeutic efficacy and safety of pulsed dye laser (PDL) in the treatment of IH.
METHODS
Seven databases were searched, including PubMed, OvidSP, Karger, Elsevier, EMBASE, Web of Science and Wiley Online Library. The review collected the characteristics of year of publication, hemangiomas cases, prior treatment, laser parameters, adverse side, pretreatment symptom, and number of response from all articles.
RESULTS
A total of 1580 studies were identified, the first round search retrieved 39 articles met inclusion criteria. Of those, only 13 articles with 1529 hemangiomas were included in the meta-analysis. This meta-analysis demonstrated an overall resolution rate of 89.1% with 6.28% incidence of adverse effect.
CONCLUSION
PDL may be the effective modality to decrease the proliferative phase and accelerate rates of involution and resolution with few adverse events.
背景
婴儿血管瘤（IH）是常见的儿科肿瘤。本荟萃分析旨在评估脉冲染料激光（PDL）治疗 IH 的疗效和安全性。
方法
检索了 7 个数据库，包括 PubMed、OvidSP、Karger、Elsevier、EMBASE、Web of Science 和 Wiley Online Library。综述收集了所有文章中关于出版年份、血管瘤病例、既往治疗、激光参数、不良反应、预处理症状和反应数量的特征。
结果
共确定了 1580 项研究，首轮搜索得到 39 项符合纳入标准的研究。其中，只有 13 项包含 1529 例血管瘤的研究被纳入荟萃分析。本荟萃分析显示，总体缓解率为 89.1%，不良反应发生率为 6.28%。
结论
PDL 可能是一种有效的治疗方法，可以减少增殖期，加速消退和缓解，且不良反应发生率低。
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