Mahyar Abolfazl, Ayazi Parviz, Orangpour Reza, Daneshi-Kohan Mohammad Mahdi, Sarokhani Mohammad Reza, Javadi Amir, Habibi Morteza, Talebi-Bakhshayesh Mousa
Department of Pediatrics, Qazvin Children Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
Korean J Pediatr. 2014 Oct;57(10):440-4. doi: 10.3345/kjp.2014.57.10.440. Epub 2014 Oct 31.
Febrile seizures are induced by fever and are the most common type of seizures in children. Although numerous studies have been performed on febrile seizures, their pathophysiology remains unclear. Recent studies have shown that cytokines may play a role in the pathogenesis of febrile seizures. The present study was conducted to identify potential links between serum interleukin-1beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and febrile seizures.
Ninety-two patients with simple or complex febrile seizures (46 patients per seizure type), and 46 controls with comparable age, sex, and severity of temperature were enrolled.
The median concentrations of serum IL-1β in the simple, complex febrile seizure, and control groups were 0.05, 0.1, and 0.67 pg/mL, respectively (P=0.001). Moreover, the median concentrations of TNF-α in the simple, complex febrile seizure, and control groups were 2.5, 1, and 61.5 pg/mL, respectively (P=0.001). Furthermore, there were significant differences between the case groups in serum IL-1β and TNF-α levels (P<0.05).
Unlike previous studies, our study does not support the hypothesis that increased IL-1β and TNF-α production is involved in the pathogenesis of febrile seizures.
热性惊厥由发热诱发，是儿童最常见的惊厥类型。尽管已针对热性惊厥开展了大量研究，但其病理生理学仍不清楚。近期研究表明，细胞因子可能在热性惊厥的发病机制中起作用。本研究旨在确定血清白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）与热性惊厥之间的潜在联系。
纳入92例单纯性或复杂性热性惊厥患者（每种惊厥类型46例），以及46例年龄、性别和体温严重程度相当的对照组。
单纯性热性惊厥组、复杂性热性惊厥组和对照组血清IL-1β的中位数浓度分别为0.05、0.1和0.67 pg/mL（P=0.001）。此外，单纯性热性惊厥组、复杂性热性惊厥组和对照组TNF-α的中位数浓度分别为2.5、1和61.5 pg/mL（P=0.001）。此外，病例组之间血清IL-1β和TNF-α水平存在显著差异（P<0.05）。
与以往研究不同，我们的研究不支持IL-1β和TNF-α产生增加参与热性惊厥发病机制的假说。
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