择期骨科手术和体外循环心脏手术会导致血清内皮抑素水平降低。
Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels.
作者信息
Åkerfeldt Torbjörn, Gunningberg Lena, Swenne Christine Leo, Ronquist Göran, Larsson Anders
机构信息
Department of Medical Sciences, Section of Clinical Chemistry, Uppsala University, Uppsala, Sweden.
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
出版信息
Eur J Med Res. 2014 Nov 8;19(1):61. doi: 10.1186/s40001-014-0061-9.
BACKGROUND
Endostatin is an endogenous inhibitor of angiogenesis that inhibits neovascularisation. The aim of the study was to evaluate the effect of elective surgery on endostatin levels.
METHODS
Blood samples were collected prior to elective surgery and 4 and 30 days postoperatively in 2 patient groups: orthopedic surgery (n =27) and coronary bypass patients (n =21). Serum endostatin levels were measured by ELISA.
RESULTS
Serum endostatin was significantly reduced 30 days after surgery in comparison with presurgical values in both the orthopedic (P =0.03) and cardiopulmonary surgery (P =0.04) group.
CONCLUSION
Serum endostatin is reduced 30 days after surgery. This reduction would favor angiogenesis and wound-healing.
背景
内皮抑素是一种抑制血管生成的内源性血管生成抑制剂。本研究的目的是评估择期手术对内皮抑素水平的影响。
方法
在两组患者中于择期手术前、术后4天和30天采集血样：骨科手术患者（n = 27）和冠状动脉搭桥患者（n = 21）。采用酶联免疫吸附测定法（ELISA）测量血清内皮抑素水平。
结果
与术前值相比，骨科手术组（P = 0.03）和心肺手术组（P = 0.04）术后30天血清内皮抑素均显著降低。
结论
术后30天血清内皮抑素降低。这种降低有利于血管生成和伤口愈合。
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