Moni Mohammad Ali, Xu Haoming, Liò Pietro
Computer Laboratory, University of Cambridge, Cambridge, UK and Department of CSE, Pabna University of Science and Technology, Pabna, Bangladesh Computer Laboratory, University of Cambridge, Cambridge, UK and Department of CSE, Pabna University of Science and Technology, Pabna, Bangladesh.
Computer Laboratory, University of Cambridge, Cambridge, UK and Department of CSE, Pabna University of Science and Technology, Pabna, Bangladesh.
Bioinformatics. 2015 Mar 15;31(6):969-71. doi: 10.1093/bioinformatics/btu731. Epub 2014 Nov 7.
CytoCom is an interactive plugin for Cytoscape that can be used to search, explore, analyse and visualize human disease comorbidity network. It represents disease-disease associations in terms of bipartite graphs and provides International Classification of Diseases, Ninth Revision (ICD9)-centric and disease name centric views of disease information. It allows users to find associations between diseases based on the two measures: Relative Risk (RR) and [Formula: see text]-correlation values. In the disease network, the size of each node is based on the prevalence of that disease. CytoCom is capable of clustering disease network based on the ICD9 disease category. It provides user-friendly access that facilitates exploration of human diseases, and finds additional associated diseases by double-clicking a node in the existing network. Additional comorbid diseases are then connected to the existing network. It is able to assist users for interpretation and exploration of the human diseases by a variety of built-in functions. Moreover, CytoCom permits multi-colouring of disease nodes according to standard disease classification for expedient visualization.
CytoCom是Cytoscape的一个交互式插件,可用于搜索、探索、分析和可视化人类疾病共病网络。它以二分图的形式表示疾病-疾病关联,并提供以国际疾病分类第九版(ICD9)为中心和以疾病名称为中心的疾病信息视图。它允许用户基于相对风险(RR)和[公式:见文本]-相关值这两种度量来查找疾病之间的关联。在疾病网络中,每个节点的大小基于该疾病的患病率。CytoCom能够根据ICD9疾病类别对疾病网络进行聚类。它提供了用户友好的访问方式,便于探索人类疾病,并通过双击现有网络中的节点来查找其他相关疾病。然后将其他共病疾病连接到现有网络。它能够通过各种内置功能帮助用户解释和探索人类疾病。此外,CytoCom允许根据标准疾病分类对疾病节点进行多色标注,以便于可视化。