Iwata Y, Amemiya K, Uchida K, Okajima H, Kuramoto H, Kenjo T, Koshimizu T, Kosuge O, Gotoda Y, Saito M
Kanagawa Medical Association of Obstetrics and Gynecology.
Nihon Sanka Fujinka Gakkai Zasshi. 1989 Jan;41(1):48-54.
Two thousand one hundred and thirty-five cases of trophoblastic disease were registered in Kanagawa Prefecture in 7 years (from 1978 to 1984). The incidence of trophoblastic diseases, hydatidiform mole, partial mole, invasive mole, choriocarcinoma and persistent trophoblastic disease (PTD) was 3.22, 1.67, 1.20, 0.07, 0.06 and 0.20, respectively, per 1,000 live births. The incidence was constant for 7 years, and did not differ significantly from that of 16 prefectures in Japan. In Kanagawa, the incidence of hydatidiform mole was less and that of partial mole was more than those in the 16 prefectures. The incidence of invasive mole and choriocarcinoma was lower and that of PTD was higher than those in the 16 prefectures. Total incidence of invasive mole, choriocarcinoma and PTD was higher in the western part of Japan, and lower in the eastern and northern parts. Kanagawa Prefecture is between these two regions. The distribution by age of hydatidiform mole was high in 25-29 y.o. and over 40 y.o. The distribution by age of partial mole tended to be similar to that of hydatidiform mole, but less remarkable. The distribution by age of invasive mole and choriocarcinoma had 2 peaks of 30-34 y.o. and 45-49 y.o. The distribution by age of PTD was between that of hydatidiform mole and choriocarcinoma.
在7年时间里（从1978年至1984年），神奈川县共登记了2135例滋养细胞疾病病例。每1000例活产中，滋养细胞疾病、葡萄胎、部分性葡萄胎、侵蚀性葡萄胎、绒毛膜癌和持续性滋养细胞疾病（PTD）的发病率分别为3.22、1.67、1.20、0.07、0.06和0.20。发病率在7年中保持稳定，与日本16个县的发病率无显著差异。在神奈川县，葡萄胎的发病率低于16个县，而部分性葡萄胎的发病率高于16个县。侵蚀性葡萄胎和绒毛膜癌的发病率低于16个县，而PTD的发病率高于16个县。侵蚀性葡萄胎、绒毛膜癌和PTD的总发病率在日本西部较高，在东部和北部较低。神奈川县位于这两个地区之间。葡萄胎的年龄分布在25 - 29岁和40岁以上人群中较高。部分性葡萄胎的年龄分布趋势与葡萄胎相似，但不太明显。侵蚀性葡萄胎和绒毛膜癌的年龄分布有两个高峰，分别在30 - 34岁和45 - 49岁。PTD的年龄分布介于葡萄胎和绒毛膜癌之间。
